Hydrochlorothiazide Impurity 12 CAS 5250-72-6
| CAS No. | 5250-72-6 |
| Molecular Formula | C6H7Cl2N3O4S2 |
| Molecular Weight | 320.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Hydrochlorothiazide Impurity 12 (CAS 5250-72-6), a pharmacopoeial impurity reference standard (molecular formula C6H7Cl2N3O4S2, MW 320.17 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C6H7Cl2N3O4S2, Hydrochlorothiazide Impurity 12 contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 320.17 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Hydrochlorothiazide Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7Cl2N3O4S2 |
| Molecular Weight | 320.17 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity 11 (CAS 671-89-6)
- Hydrochlorothiazide Impurity 34 (CAS CATO-C4X-117734)
- Hydrochlorothiazide Impurity 55 (CAS CATO-C4X-117755)
- Hydrochlorothiazide impurity 45 (CAS CATO-C4X-117745)
- Hydrochlorothiazide impurity 46 (CAS CATO-C4X-117746)
- Hydrochlorothiazide Impurity 14 (CAS 1668-63-9)
- Hydrochlorothiazide Impurity 10 (CAS CATO-C4X-117710)
- Hydrochlorothiazide Impurity 29 (CAS 1753-71-5)
Recommended Standards
- rel-(3aR,4S,6aS)-4-[(3-iodo-1-bicyclo[1.1.1]pentanyl)methyl]-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan (CAS 2374231-26-0)
- 1,3-Bis(2,2,3,3-tetrafluoropropoxy)propan-2-ol (CAS 1024024-65-4)
- N-[(1H-1,3-Benzodiazol-2-yl)methyl]-3,4-dichlorobenzamide (CAS 338771-75-8)
- methyl 8-bromo-3-nitro-naphthalene-1-carboxylate (CAS 1082722-33-5)
- Nabumetone Impurity 22 (CAS 36795-50-3)
- Tamsulosin Impurity 38 (CAS 116091-64-6)
- Posaconazole Impurity 73 (CAS 1370190-94-5 (free base))
- Budesonide (CAS 51333-22-3)
- 2-Cyclopropenone (CAS 2961-80-0)
- 1-[(3aR,8aR)-Tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-yl]pyrrolidine (CAS 913706-72-6)
- (6-(Indolin-1-yl)-2-methylpyridin-3-yl)methanamine (CAS 1355225-53-4)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoic acid (CAS 205812-06-2)
- Pyrene-amido-PEG4-azide (CAS 1817735-36-6)
- Experimental Allergic Encephalitogenic Peptide (CAS 29705-92-8)
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