Hydrochlorothiazide Impurity 34 CAS CATO-C4X-117734
| CAS No. | CATO-C4X-117734 |
| Molecular Formula | C8H10ClNO6S2 |
| Molecular Weight | 315.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Hydrochlorothiazide Impurity 34.
CATO supplies Hydrochlorothiazide Impurity 34 (CAS CATO-C4X-117734), a pharmacopoeial impurity reference standard (molecular formula C8H10ClNO6S2, MW 315.75 g/mol) used for the identification and quantification of trace impurities in APIs.
Hydrochlorothiazide Impurity 34 (C8H10ClNO6S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10ClNO6S2 |
| Molecular Weight | 315.75 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide impurity 45 (CAS CATO-C4X-117745)
- Hydrochlorothiazide impurity 46 (CAS CATO-C4X-117746)
- Hydrochlorothiazide Impurity 14 (CAS 1668-63-9)
- Hydrochlorothiazide Impurity 10 (CAS CATO-C4X-117710)
- Hydrochlorothiazide Impurity 29 (CAS 1753-71-5)
- Hydrochlorothiazide Impurity 31 (CAS 890-67-5)
- Hydrochlorothiazide Impurity 18 (CAS 89813-56-9)
- Hydrochlorothiazide Impurity 12 (CAS 5250-72-6)
Recommended Standards
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- Pinaverium Bromide Impurity 20 (CAS CATO-C4X-246720)
- Palbociclib Impurity 174 (CAS CATO-C4X-1125174)
- Cefmetazole Impurity 38 (CAS CATO-C4X-150738)
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