Hydrochlorothiazide impurity 45 CAS CATO-C4X-117745
| CAS No. | CATO-C4X-117745 |
| Molecular Formula | C8H11ClN2O5S2 |
| Molecular Weight | 314.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Hydrochlorothiazide impurity 45 (C8H11ClN2O5S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Hydrochlorothiazide impurity 45 (CAS CATO-C4X-117745), a pharmacopoeial impurity reference standard (molecular formula C8H11ClN2O5S2, MW 314.77 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Hydrochlorothiazide impurity 45 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H11ClN2O5S2 |
| Molecular Weight | 314.77 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide impurity 46 (CAS CATO-C4X-117746)
- Hydrochlorothiazide Impurity 34 (CAS CATO-C4X-117734)
- Hydrochlorothiazide Impurity 14 (CAS 1668-63-9)
- Hydrochlorothiazide Impurity 10 (CAS CATO-C4X-117710)
- Hydrochlorothiazide Impurity 29 (CAS 1753-71-5)
- Hydrochlorothiazide Impurity 31 (CAS 890-67-5)
- Hydrochlorothiazide Impurity 18 (CAS 89813-56-9)
- Hydrochlorothiazide Impurity 24 (CAS 1025-75-8)
Recommended Standards
- 478043-50-4 2-Chloro-N-(4-methoxyphenyl)-1-methyl-1H-indole-3-carboxamide MFCD01814446 (CAS 478043-50-4)
- Temazepam impurity G CRS (CAS 93329-92-1)
- N-Nitroso Chlorphenamine (CAS CATO-C4X-118844)
- N6-Allyl-N4-(3-chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine (CAS 894193-69-2)
- Tepotinib Impurity 36 (CAS 1103507-25-0)
- Ruxolitinib Impurity 232 (CAS CATO-C4X-2058232)
- Pomalidomide Impurity 47 (CAS 885278-16-0)
- 2-(Pyrimidin-2-yl)propanoic acid (CAS 819850-16-3)
- 4-(4-(2-Fluorophenyl)piperazin-1-yl)-N,N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine (CAS 339105-20-3)
- trans-4-(Bis(4-methoxybenzyl)amino)cyclohexanol (CAS 1349185-17-6)
- 1-tert-Butyl 2-ethyl 3,3-difluoropyrrolidine-1,2-dicarboxylate (CAS 1881265-72-0)
- Methyl 3,4-diamino-5-iodobenzoate (CAS 1258940-57-6)
- 2,5-Diethynylaniline (CAS 137000-70-5)
- Semaglutide Impurity 157 (x TFA Salt) (CAS CATO-C4X-2226157)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com