Hydrochlorothiazide Impurity 11 CAS 671-89-6
| CAS No. | 671-89-6 |
| Molecular Formula | C6H4Cl3NO4S2 |
| Molecular Weight | 324.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Hydrochlorothiazide Impurity 11 (C6H4Cl3NO4S2) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 324.59 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Hydrochlorothiazide Impurity 11 (CAS 671-89-6), a pharmacopoeial impurity reference standard (molecular formula C6H4Cl3NO4S2, MW 324.59 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4Cl3NO4S2 |
| Molecular Weight | 324.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Hydrochlorothiazide Standards
- Hydrochlorothiazide Impurity 55 (CAS CATO-C4X-117755)
- Hydrochlorothiazide Impurity 22 (CAS 63779-86-2)
- Hydrochlorothiazide Impurity 12 (CAS 5250-72-6)
- Hydrochlorothiazide 5-Chloro Impurity (CAS 5233-42-1)
- Hydrochlorothiazide Impurity 34 (CAS CATO-C4X-117734)
- Hydrochlorothiazide impurity 45 (CAS CATO-C4X-117745)
- Hydrochlorothiazide impurity 46 (CAS CATO-C4X-117746)
- Hydrochlorothiazide Impurity 14 (CAS 1668-63-9)
Recommended Standards
- 9-((Trimethylsilyl)methyl)-6-(((trimethylsilyl)methyl)thio)-9H-purine (CAS 93629-49-3)
- 4-Bromo-N-(2-chloro-4-methylphenyl)benzamide (CAS 1004185-21-0)
- 7-Chloro-N-(3,4-dichlorophenyl)quinazolin-4-amine (CAS 477856-32-9)
- 2-(1-((4-Bromophenyl)imino)ethyl)-4-chlorophenol (CAS 105533-45-7)
- Cabotegravir Impurity 18 (CAS CATO-C4X-287618)
- Ertugliflozin impurity 02 (CAS 1210344-83-4)
- Brivaracetam Impurity 5 (CAS 943986-67-2)
- 189109-45-3 Byzantionoside B C19H32O7 W2295 (CAS 189109-45-3)
- Triethoxy[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]silane (CAS 561069-04-3)
- (S)-1,2,3,4-Tetrahydroquinolin-4-amine dihydrochloride (CAS 1965305-30-9)
- 1-Bromo-4-(isopropylsulfonyl)naphthalene (CAS 1399658-79-7)
- 3-(1,3-Dimethyl-1H-pyrazol-4-yl)acrylic acid (CAS 514800-75-0)
- (S)-2-Amino-2-methylhex-5-enoic acid (CAS 1011309-60-6)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com