3-(4-Chlorophenyl)-6-fluoro-4-methylcoumarin CAS 527751-38-8
| CAS No. | 527751-38-8 |
| Molecular Formula | C16H10ClFO2 |
| Molecular Weight | 288.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(4-Chlorophenyl)-6-fluoro-4-methylcoumarin.
CATO supplies 3-(4-Chlorophenyl)-6-fluoro-4-methylcoumarin (CAS 527751-38-8), a certified reference material (molecular formula C16H10ClFO2, MW 288.70 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system, 3-(4-Chlorophenyl)-6-fluoro-4-methylcoumarin is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 288.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(4-Chlorophenyl)-6-fluoro-4-methylcoumarin meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H10ClFO2 |
| Molecular Weight | 288.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
Related Chlorophenyl Standards
- 4-(4-chlorophenyl)-3-(4-fluorophenyl)-1,2-oxazol-5-amine (CAS 1097153-49-5)
- 2-(1-(4-Chlorophenyl)-1H-pyrazol-5-yl)-5-fluorophenol (CAS 876950-42-4)
- 3-(2-Chlorophenyl)-2-(fluoromethyl)quinazolin-4(3H)-one (CAS 61554-54-9)
- 3-(2-Chlorophenyl)-6-fluoro-2-methylquinazolin-4(3H)-one (CAS 49579-12-6)
- 3-(3-Chlorophenyl)-6-fluoro-4-methylcoumarin (CAS 527751-40-2)
- 1-(3-Chlorophenyl)-5-(furan-2-yl)-1h-pyrazole-3-carboxylic acid (CAS 957013-17-1)
- 1-(4-Chlorophenyl)-5-(furan-2-yl)-1h-pyrazole-3-carboxylic acid (CAS 956769-53-2)
- 4-(4-Chlorophenyl)-1-(6-fluoropyridin-2-yl)-1H-pyrazol-3-amine (CAS 318284-44-5)
Recommended Standards
- 3-Chloro-6-ethoxy-2-fluoro-5-(2-methyl-1,3-dioxolan-2-yl)benzaldehyde (CAS 1995889-49-0)
- 4-Chloro-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)phenol (CAS 321534-47-8)
- 4-Chloro-6-fluoro-2-(4-methoxy-phenyl)-quinazoline (CAS 885277-16-7)
- 3-(2-Chloro-6-fluorobenzyl)-5-phenyl-1,2,4-oxadiazole (CAS 6180-87-6)
- 4-Bromo-2-methylthioanisole (CAS 89981-03-3)
- 1,1-Bis(trimethylsilyloxy)-1-propene (CAS 31469-22-4)
- 4-Amino-5-(4-chlorobenzoyl)-2-[(2-cyano-4,5-dimethoxyphenyl)amino]thiophene-3-carbonitrile (CAS 338959-75-4)
- Piracetam EP Impurity 4 (CAS 22126-44-9)
- 2-Propenoic acid, 2-methyl-, 2-(ethenyloxy)ethyl ester (CAS 1464-69-3)
- 1215295-98-9 3-Ethyl-1,2-oxazole-5-carbonitrile DTXSID30673680 (CAS 1215295-98-9)
- (1h-Indole-2-carbonyl)-l-valine (CAS 1072856-64-4)
- n-(3-Bromobenzyl)cyclopropanamine (CAS 892570-95-5)
- 1-(4H-Furo[3,2-b]pyrrol-5-yl)ethanone (CAS 60664-19-9)
- Semaglutide Impurity 121 X Sodium Salt (CAS CATO-C4X-2226121)
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