3-(3-Chlorophenyl)-6-fluoro-4-methylcoumarin CAS 527751-40-2
| CAS No. | 527751-40-2 |
| Molecular Formula | C16H10ClFO2 |
| Molecular Weight | 288.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(3-Chlorophenyl)-6-fluoro-4-methylcoumarin (C16H10ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies 3-(3-Chlorophenyl)-6-fluoro-4-methylcoumarin (CAS 527751-40-2), a certified reference material (molecular formula C16H10ClFO2, MW 288.70 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(3-Chlorophenyl)-6-fluoro-4-methylcoumarin meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H10ClFO2 |
| Molecular Weight | 288.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
Related Chlorophenyl Standards
- 4-(4-chlorophenyl)-3-(4-fluorophenyl)-1,2-oxazol-5-amine (CAS 1097153-49-5)
- 2-(1-(4-Chlorophenyl)-1H-pyrazol-5-yl)-5-fluorophenol (CAS 876950-42-4)
- 3-(2-Chlorophenyl)-2-(fluoromethyl)quinazolin-4(3H)-one (CAS 61554-54-9)
- 3-(2-Chlorophenyl)-6-fluoro-2-methylquinazolin-4(3H)-one (CAS 49579-12-6)
- 3-(4-Chlorophenyl)-6-fluoro-4-methylcoumarin (CAS 527751-38-8)
- 1-(3-Chlorophenyl)-5-(furan-2-yl)-1h-pyrazole-3-carboxylic acid (CAS 957013-17-1)
- 1-(4-Chlorophenyl)-5-(furan-2-yl)-1h-pyrazole-3-carboxylic acid (CAS 956769-53-2)
- 4-(4-Chlorophenyl)-1-(6-fluoropyridin-2-yl)-1H-pyrazol-3-amine (CAS 318284-44-5)
Recommended Standards
- 3-Chloro-6-ethoxy-2-fluoro-5-(2-methyl-1,3-dioxolan-2-yl)benzaldehyde (CAS 1995889-49-0)
- 3-(2-Chloro-6-fluorobenzyl)-5-phenyl-1,2,4-oxadiazole (CAS 6180-87-6)
- 4-Chloro-2-(5-(4-fluorophenyl)-1H-pyrazol-3-yl)phenol (CAS 321534-47-8)
- 2-Chloro-N-[4-(3,4-difluorophenyl)-1,3-thiazol-2-yl]acetamide (CAS 554405-16-2)
- 3-Amino-5-bromo-4-fluorobenzoic acid (CAS 1290117-11-1)
- Colistin A Sulfate Hydrate (CAS CATO-CCAD303449)
- 2-Oxo-3-phenylpropanenitrile (CAS 33472-02-5)
- (S)-2-amino-4-methyl-N-(2-morpholinoethyl)pentanamide hydrochloride (CAS 1243259-14-4)
- 3-Allyl-2-thioxo-2,3,5,6,7,8-hexahydroquinazolin-4(1H)-one (CAS 5313-48-4)
- Tert-butyl 4-carbamoyl-4-(cyclopropylamino)piperidine-1-carboxylate (CAS 1344702-28-8)
- 2-Amino-3-acetylpyridine (CAS 65326-33-2)
- 2,4-Dimethoxythiophenol (CAS 18906-37-1)
- Sodium (E)-2-((1-oxido-7-(phenylamino)-3-sulfonaphthalen-2-yl)diazenyl)benzoate (CAS 6369-32-0)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
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