8-Fluoro-4-methylquinolin-2-ol CAS 5279-86-7
| CAS No. | 5279-86-7 |
| Molecular Formula | C10H8FNO |
| Molecular Weight | 177.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 8-Fluoro-4-methylquinolin-2-ol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 177.18 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
8-Fluoro-4-methylquinolin-2-ol (CAS 5279-86-7), molecular formula C10H8FNO and molecular weight 177.18 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8FNO |
| Molecular Weight | 177.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 5-Fluoro-2-(1h-pyrazol-1-yl)aniline (CAS 1006960-35-5)
- 7-Fluoro-2-methylquinazolin-4-amine (CAS 1009036-30-9)
- 3-(3-Fluoro-4-methylphenyl)-3-oxopropanenitrile (CAS 1016770-89-0)
- 6-FLUORO-7-METHOXY-ISOQUINOLINE (CAS 1036711-00-8)
- 8-Fluoro-4-methylisoquinolin-1(2H)-one (CAS 1050203-45-6)
- 6-Fluoro-8-methylquinolin-4-ol (CAS 1065092-74-1)
- 7-Fluoro-8-methylquinolin-4-ol (CAS 1065092-79-6)
- 6-Fluoro-8-hydroxy-2-methylquinoline (CAS 1070897-08-3)
Recommended Standards
- 8-Fluoro-4-methoxyquinoline (CAS 942035-83-8)
- 8-Fluoro-5-methoxyquinoline (CAS 887769-93-9)
- 8-Fluoro-4-hydrazinylquinoline (CAS 49611-99-6)
- 8-Fluoro-6-methoxyquinoline (CAS 209353-21-9)
- 2-(2-Isopropylphenyl)acetonitrile (CAS 91131-80-5)
- N-cyclooctyltetrahydro-2H-thiopyran-4-amine (CAS 1153349-00-8)
- 1-(2-Chloro-5-nitropyridin-4-yl)ethanol (CAS 1214241-89-0)
- 11β-Hydroxy-16α-methyl-17,20:20,21-bis(methylenedioxy)-pregn-1,4-dien-3-one (CAS 110428-42-7)
- tert-Butyl (1R,4R,7S)-7-hydroxy-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (CAS 1228112-72-8)
- (2-Methylcyclopentyl)methanesulfonamide (CAS 1695877-80-5)
- 2,4-Difluoro-3-(trifluoromethyl)pyridine (CAS 1227564-69-3)
- 2-methyl-7-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole (CAS 845751-67-9)
- Methyl 5-methyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylate (CAS 1367666-62-3)
- Boc-Cholecystokinin Octapeptide (desulfated) (A-1295.0001) (CAS 25687-34-7)
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