Roflumilast Impurity 13 CAS 53173-70-9
| CAS No. | 53173-70-9 |
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Roflumilast Impurity 13 (CAS 53173-70-9) is a certified pharmaceutical impurity reference standard with the molecular formula C8H6F2O3 and a molecular weight of 188.13 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Roflumilast Impurity 13 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 188.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Roflumilast Impurity 13 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | F-containing |
Related Roflumilast Standards
- Roflumilast impurity 19 (CAS 151103-08-1)
- Roflumilast Impurity 17 (CAS 91872-02-5)
- Roflumilast Impurity 11 (CAS 159783-78-5)
- Roflumilast impurity 25 (CAS 1243391-44-7)
- Roflumilast Impurity 31 (CAS 268225-79-2)
- Roflumilast USP Related Compound C (CAS 22889-78-7)
- Roflumilast Impurity 30 (CAS 34809-82-0)
- Roflumilast impurity 22 (CAS 343927-62-8)
Recommended Standards
- 3-(difluoromethoxy)-2-hydroxybenzaldehyde (CAS 1806293-28-6)
- 1-carbomethoxy-1-methyl-4-(4-methyl-3-pentenyl)-3-cyclohexene 2179-79-5 AR-1C2189 (CAS 2179-79-5)
- Nemonoxacin Impurity 35 (CAS 1781915-09-0)
- Methyl 2-amino-3,5-difluoroisonicotinate (CAS 2803703-94-6)
- Semaglutide Impurity 15 (CAS CATO-C4X-222615)
- Upadacitinib Impurity 109 (CAS CATO-C4X-2405109)
- Faropenem Impurity 64 (CAS CATO-C4X-128964)
- N,N'-(4,5-dimethyl-1,2-phenylene)diacetamide (CAS 202131-86-0)
- N-((1,3-Dimethyl-1H-pyrazol-4-yl)methyl)-1-ethyl-5-methyl-1H-pyrazol-4-amine hydrochloride (CAS 1856032-15-9)
- (Z)-Ethoxy({1-[4-(pyrazin-2-yloxy)phenyl]ethylidene})amine (CAS 866157-16-6)
- tert-butyl (2S)-2-methyl-4-methylene-piperidine-1-carboxylate (CAS 2816820-18-3)
- 4-Benzyl-N-(2-ethylphenyl)piperazine-1-carboxamide (CAS 890570-79-3)
- 3-[3-oxo-4-(2-phenylethyl)-3,4-dihydroquinoxalin-2-yl]propanoic acid (CAS 721426-15-9)
- Semaglutide Impurity 165 (CAS CATO-C4X-2226165)
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