Nintedanib Impurity 44 CAS 3395-80-0
| CAS No. | 3395-80-0 |
| Molecular Formula | C9H11ClO2 |
| Molecular Weight | 186.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nintedanib Impurity 44.
Nintedanib Impurity 44 (CAS 3395-80-0) is a certified pharmaceutical impurity reference standard with the molecular formula C9H11ClO2 and a molecular weight of 186.64 g/mol.
Structurally, Nintedanib Impurity 44 (C9H11ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 186.64 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11ClO2 |
| Molecular Weight | 186.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 39 (CAS 3395-81-1)
- Nintedanib Impurity 45 (CAS 70380-66-4)
- Nintedanib Impurity 67 (CAS 40872-87-5)
- Nintedanib Impurity 184 (CAS 873376-89-7)
- Nintedanib Impurity 38 (CAS 58378-33-9)
- Nintedanib Impurity 42 (CAS 2186-92-7)
- Nintedanib Impurity 43 (CAS 59276-28-7)
- Nintedanib Impurity 66 (CAS 707-07-3)
Recommended Standards
- Verapamil Impurity 27 (CAS 7306-46-9)
- 1-(3-Chloro-2-methylpropyl)-2-fluoro-benzene (CAS 101975-64-8)
- Verapamil Impurity 25 (CAS 3893-01-4)
- 1-(1-Chlorobutan-2-yl)-4-fluorobenzene (CAS 1225846-66-1)
- Vericiguat Impurity 10 (CAS CATO-C4X-289610)
- Peramivir Impurity 87 (CAS CATO-C4X-183387)
- Rivaroxaban Impurity 99 (CAS CATO-C4X-109099)
- 3-[4-(chloromethyl)-1,3-oxazol-2-yl]benzonitrile (CAS 1126634-12-5)
- 4-Diethylaminophenyl isothiocyanate (CAS 84381-54-4)
- 2-(3,4-Dimethylphenyl)pyridine (CAS 4423-81-8)
- N,N-Diethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethanamine (CAS 1086111-20-7)
- N-(4-Cyclohexylphenyl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide (CAS 882082-17-9)
- 2-((Benzo[d][1,3]dioxol-5-ylmethyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate (CAS 387854-26-4)
- Peptide Impurity (CAS CATO-CPTD788810)
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