Spironolactone EP Impurity H CAS 53866-24-3
| CAS No. | 53866-24-3 |
| Molecular Formula | C20H26O2 |
| Molecular Weight | 298.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Spironolactone EP Impurity H (CAS 53866-24-3, C20H26O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, Spironolactone EP Impurity H is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 298.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Spironolactone EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H26O2 |
| Molecular Weight | 298.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
Related Spironolactone Standards
- Spironolactone Impurity 13 (CAS CATO-C4X-134513)
- Spironolactone Gammalactone Impurity (CAS 20802-57-7)
- Spironolactone Impurity 10 (CAS 53866-23-2)
- Spironolactone Impurity 17 (CAS CATO-C4X-134517)
- Spironolactone Impurity 16 (CAS CATO-C4X-134516)
- Spironolactone EP Impurity F (CAS 976-71-6)
- Spironolactone EP Impurity C (CAS 976-70-5)
- Spironolactone Impurity 19 (CAS CATO-C4X-134519)
Recommended Standards
- Diphenhydramine impurity 18 (CAS 150556-79-9)
- Dexamethasone Impurity 110 (CAS 1651862-82-6)
- Betamethasone Impurity 126 (CAS 90039-84-2)
- ({[Cyclopentyl(thien-2-ylmethyl)amino]-carbonothioyl}amino)acetic acid 656815-48-4 7517AE C13H18N2O2S2 (CAS 656815-48-4)
- Aztreonam Impurity 108 (CAS CATO-C4X-1522108)
- Carbazochrome Impurity 23 (CAS CATO-C4X-229123)
- Atorvastatin impurity 165 (CAS CATO-C4X-1132165)
- cis-4-Hydroxytetrahydrofuran-2-carboxylic acid (CAS 2209-08-7)
- 3-(Benzylamino)-1-phenylpyrrolidine-2,5-dione (CAS 7685-88-3)
- Tert-butyl 4-(2-methoxybenzamido)piperidine-1-carboxylate (CAS 1233955-73-1)
- N-(1-(2-Chloroacetyl)pyrrolidin-3-yl)-N-isopropylacetamide (CAS 1353983-16-0)
- 5,5-Dimethyl-5,6-dihydrobenzofuran-7(4H)-one (CAS 191480-96-3)
- Methyl 3-(4-isopropyl-N-methylphenylsulfonamido)thiophene-2-carboxylate (CAS 1325304-90-2)
- Peptide 438 (CAS CATO-CPTD788438)
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