Spironolactone Impurity 10 CAS 53866-23-2
| CAS No. | 53866-23-2 |
| Molecular Formula | C22H32O2 |
| Molecular Weight | 328.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Spironolactone Impurity 10 (CAS 53866-23-2, C22H32O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, Spironolactone Impurity 10 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 328.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Spironolactone Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H32O2 |
| Molecular Weight | 328.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
Related Spironolactone Standards
- Spironolactone Impurity 17 (CAS CATO-C4X-134517)
- Spironolactone Impurity 16 (CAS CATO-C4X-134516)
- Spironolactone EP Impurity F (CAS 976-71-6)
- Spironolactone EP Impurity C (CAS 976-70-5)
- Spironolactone Impurity 19 (CAS CATO-C4X-134519)
- Spironolactone Gammalactone Impurity (CAS 20802-57-7)
- Spironolactone Impurity 13 (CAS CATO-C4X-134513)
- Spironolactone EP Impurity H (CAS 53866-24-3)
Recommended Standards
- (9-cis,13-cis)-Retinoic Acid Ethyl Ester 86708-68-1 (CAS 86708-68-1)
- Progesterone EP Impurity I (S-isomer) (CAS 3986-89-8)
- CAS 749266-38-4 (CAS 749266-38-4)
- Progesterone EP Impurity I (CAS 24254-01-1)
- Upadacitinib Impurity 84 2HCl (CAS CATO-C4X-240584)
- Milrinone Impurity 35 (CAS 52600-51-8)
- rac-Formoterol Impurity 57 HCl (CAS CATO-C4X-152588)
- 2,2'-(((9H-Fluorene-9,9-diyl)bis(2-methyl-4,1-phenylene))bis(oxy))diethanol (CAS 156326-34-0)
- (S)-1-Boc-Alpha-(Fmoc-Amino)-4-Piperidinebutanoic acid (CAS 313052-18-5)
- 2-(4-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-yl)acetic acid (CAS 946682-30-0)
- Finasteride Impurity 11 (CAS 1346602-40-1)
- (4-Iodo-3,5-dimethylpyridin-2-yl)methyl acetate (CAS 848696-82-2)
- Xanomeline impurity N1 (CAS 159059-10-6)
- Galanin-Like Peptide (human) trifluoroacetate salt (CAS 245114-99-2)
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