Spironolactone EP Impurity F CAS 976-71-6
| CAS No. | 976-71-6 |
| Molecular Formula | C22H28O3 |
| Molecular Weight | 340.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Spironolactone EP Impurity F (CAS 976-71-6) is a certified pharmaceutical impurity reference standard with the molecular formula C22H28O3 and a molecular weight of 340.46 g/mol.
Spironolactone EP Impurity F (C22H28O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28O3 |
| Molecular Weight | 340.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Spironolactone Standards
- Spironolactone Impurity 16 (CAS CATO-C4X-134516)
- Spironolactone EP Impurity C (CAS 976-70-5)
- Spironolactone Impurity 17 (CAS CATO-C4X-134517)
- Spironolactone Impurity 19 (CAS CATO-C4X-134519)
- Spironolactone Impurity 10 (CAS 53866-23-2)
- Spironolactone Impurity 12 (CAS CATO-C4X-134512)
- Spironolactone Gammalactone Impurity (CAS 20802-57-7)
- Spironolactone Impurity 13 (CAS CATO-C4X-134513)
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