S-Adenosyl-L-Methionine Impurity 20 CAS 54447-84-6
| CAS No. | 54447-84-6 |
| Molecular Formula | C20H24N10O12P2 |
| Molecular Weight | 658.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), S-Adenosyl-L-Methionine Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, S-Adenosyl-L-Methionine Impurity 20 (CAS 54447-84-6, C20H24N10O12P2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of S-Adenosyl-L-Methionine Impurity 20 (C20H24N10O12P2) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H24N10O12P2 |
| Molecular Weight | 658.41 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Nitrogen Atoms | 10 |
Related S Standards
- S-Adenosyl-L-Methionine Impurity 17 (CAS 2095880-61-6)
- S-Adenosyl-L-Methionine Impurity 13 (CAS CATO-C4X-138113)
- S-Adenosyl-L-Methionine Impurity 14 (CAS CATO-C4X-138114)
- S-Adenosyl-L-Methionine-d3 (CAS CATO-C4X-138122)
- S-Adenosyl-D-methionine (CAS 14031-35-7)
- S-Adenosyl-L-Methionine (CAS 29908-03-0)
- S-(5'-Adenosyl)-L-homocysteine (CAS 979-92-0)
- Adenosyl Methionine Impurity 8 (CAS 59987-48-3)
Recommended Standards
- 2,5-Bis(1,1-dimethylethyl) 3,6-bis(5-bromo-2-thienyl)-1,4-dioxopyrrolo[3,4-c]pyrrole-2,5(1H,4H)-dicarboxylate (CAS 1046864-84-9)
- N,N'-(ethane-1,2-diyl)bis(4-chloro-N-(3-chlorobenzyl)benzenesulfonamide) (CAS 338775-08-9)
- 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-(4-sulfamoylphenyl)benzofuran-6-sulfonamide (CAS 959324-50-6)
- Dichlorobis[3-(diphenylphosphino]propylamine]ruthenium(II) (CAS 1196467-26-1)
- Alectinib Impurity 92 (CAS CATO-C4X-283692)
- Eltrombopag Impurity 85(E-Isomer) (CAS CATO-C4X-119885)
- Carfilzomib Impurity D3 (CAS CATO-C4X-102258)
- CAS 10102-17 (CAS 10102-17)
- 2-(5-Bromo-2-fluorophenyl)-2-methyl-1,3-dioxolane (CAS 1555385-37-9)
- 1-(Methylsulfonyl)-3-pyrroline (CAS 246540-50-1)
- 2-(Aminomethyl)-3-(difluoromethyl)-6-(trifluoromethyl)pyridine-4-acetonitrile (CAS 1361884-29-8)
- 3-Morpholino-4-oxo-4-((tetrahydrofuran-2-yl)methoxy)butanoic acid (CAS 835907-12-5)
- Difelikefalin (CAS 1024828-77-0)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
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