Clonidine EP Impurity B CAS 54707-71-0
| CAS No. | 54707-71-0 |
| Molecular Formula | C11H11Cl2N3O |
| Molecular Weight | 272.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clonidine EP Impurity B.
As a process- or degradation-related impurity, Clonidine EP Impurity B (CAS 54707-71-0, C11H11Cl2N3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clonidine EP Impurity B (C11H11Cl2N3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 272.13 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Clonidine EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H11Cl2N3O |
| Molecular Weight | 272.13 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Clonidine Standards
Recommended Standards
- N-(2,4-dichlorophenyl)-3-methyl-2,3-dihydro-1H-imidazole-4-carboxamide (CAS 866154-56-5)
- Methyl 2-amino-5-bromo-4-isopropylbenzoate (CAS 1000018-13-2)
- Methyl 4,5-dichloro-1,6-dimethyl-1H-indole-2-carboxylate (CAS 2244453-95-8)
- N-(2-Bromoethyl)-4-ethoxybenzamide (CAS 100129-14-4)
- Amiodarone Impurity 12 (CAS 4265-27-4)
- Irbesartan Impurity 43 (CAS CATO-C4X-166643)
- Olaparib Impurity 123 (CAS CATO-C4X-1135123)
- 2-(3-Mercaptopropyl)isoindoline-1,3-dione (CAS 39801-32-6)
- (2-Amino-3-(difluoromethyl)-6-iodopyridin-4-yl)methanol (CAS 1806915-10-5)
- 2-{[(3-aminophenyl)carbamoyl]amino}acetamide (CAS 1040058-29-4)
- n-Benzylpiperazine-1-carboxamide (CAS 202819-47-4)
- (R)-6-methylchroman-4-amine hydrochloride (CAS 730980-47-9)
- (1Z)-1-(Thiophen-3-yl)-N-(4H-1,2,4-triazol-4-yl)methanimine (CAS 125142-81-6)
- Peptide Impurity 41 (CAS CATO-CPTD788841)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com