Clonidine Impurity 2 CAS 10113-35-6
| CAS No. | 10113-35-6 |
| Molecular Formula | C7H5Cl2NO |
| Molecular Weight | 190.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Clonidine Impurity 2 (C7H5Cl2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Clonidine Impurity 2 (CAS 10113-35-6), a pharmacopoeial impurity reference standard (molecular formula C7H5Cl2NO, MW 190.03 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5Cl2NO |
| Molecular Weight | 190.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Clonidine Standards
- Clonidine Impurity 5 (CAS 39075-78-0)
- Clonidine EP Impurity C (CAS 608-31-1)
- Clonidine (CAS 4205-90-7)
- Clonidine Impurity 3 (CAS 27806-81-1)
- Clonidine Impurity 1 (CAS 21709-18-2)
- Clonidine Hydrochloride EP Impurity A (CAS 5391-39-9)
- Clonidine Impurity 7 (CAS CATO-C4X-15947)
- Clonidine EP Impurity B (CAS 54707-71-0)
Recommended Standards
- 4-Chloro-6-methylnicotinoyl chloride (CAS 1005515-30-9)
- 2-Chloro-1-(5-chloropyridin-2-yl)ethan-1-one (CAS 103962-11-4)
- 5-Bromo-1,3,4-thiadiazole-2-carbonitrile (CAS 916889-37-7)
- 1-(4,6-Dichloropyridin-2-yl)ethanone (CAS 1060815-12-4)
- Atrasentan Impurity 167 (CAS 1059043-40-1)
- Ibuprofen Impurity 53 (CAS CATO-C4X-108253)
- Gliquidone Impurity 12 (CAS CATO-C4X-300012)
- 2-(1-(3-Methoxypropyl)-4-methyl-1H-pyrrol-2-yl)pyridine (CAS 800369-40-8)
- 7-Bromo-8-fluoro-6-iodo-2-(methylthio)quinazolin-4(1H)-one (CAS 2757096-60-7)
- Diethyl (cyanofluoromethyl)phosphonate (CAS 109626-99-5)
- 3-Amino-3-(5-(2-(trifluoromethyl)phenyl)furan-2-yl)propanamide (CAS 771522-81-7)
- 1417569-96-0 4-Pyrimidin-2-ylpiperazine-1-carboximidamide sulfate MFCD22422004 (CAS 1417569-96-0)
- 2-Bromo-5-chloro-3-fluoropyridine (CAS 514797-97-8)
- Peptide YY (3-36) (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 126339-09-1)
Why CATO?
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