Butylphthalide Impurity 2 CAS 551-08-6
| CAS No. | 551-08-6 |
| Molecular Formula | C12H12O2 |
| Molecular Weight | 188.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Butylphthalide Impurity 2.
As a process- or degradation-related impurity, Butylphthalide Impurity 2 (CAS 551-08-6, C12H12O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Butylphthalide Impurity 2 (C12H12O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 188.22 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Butylphthalide Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12O2 |
| Molecular Weight | 188.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Butylphthalide Standards
- Butylphthalide Impurity N7 (CAS 76681-73-7)
- Butylphthalide Impurity 22 (CAS 14570-43-5)
- Butylphthalide Impurity 75 (CAS 72917-31-8)
- Butylphthalide Impurity 79 (CAS 56014-87-0)
- Butylphthalide Impurity 26 (CAS 20871-40-3)
- Butylphthalide Impurity 8 (CAS 1505458-11-6)
- Butylphthalide Impurity 7 (CAS 122654-56-2)
- Butylphthalide Impurity 41 (CAS 3413-15-8)
Recommended Standards
- Avibactam impurity 100 (CAS CATO-C4X-1348100)
- Pregabalin impurity 94 (CAS 39520-22-4)
- Pregabalin Impurity 2 (CAS 75143-89-4)
- Sodium Valproate Impurity 44 (CAS 4441-94-5)
- Azilsartan Impurity 49 (CAS CATO-C4X-109649)
- Promethazine Impurity 67 (CAS 7647-63-4)
- Salbutamol Glyoxal Impurity (CAS 72189-44-7)
- 4-(2-Methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 1039931-72-0)
- Atogepant Impurity 60 (CAS CATO-C4X-328560)
- 3-(3,5-Dimethylphenoxy)propane-1-sulfonyl chloride (CAS 1018340-65-2)
- (Z)-1-(4-(benzyloxy)phenyl)ethan-1-one oxime (CAS 75408-90-1)
- 7-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)dibenzo[c,h]acridine (CAS 1441062-49-2)
- Imidazo[1,2-b]pyridazinium, 6-chloro-1,7,8-trimethyl- (CAS 738520-04-2)
- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
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