3-Amino-4-chloro-N-(2-iodo-5-methylphenyl)benzene-1-sulfonamide CAS 554405-05-9
| CAS No. | 554405-05-9 |
| Molecular Formula | C13H12ClIN2O2S |
| Molecular Weight | 422.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Amino-4-chloro-N-(2-iodo-5-methylphenyl)benzene-1-sulfonamide (CAS 554405-05-9), molecular formula C13H12ClIN2O2S and molecular weight 422.67 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Amino-4-chloro-N-(2-iodo-5-methylphenyl)benzene-1-sulfonamide (C13H12ClIN2O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H12ClIN2O2S |
| Molecular Weight | 422.67 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 4-Amino-2-(hexadecylthio)-6-(methylthio)pyrimidine-5-carbonitrile (CAS 922526-97-4)
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Recommended Standards
- 3-(5,6-Dichloro-1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (CAS 338774-13-3)
- Calcitriol-d6 (CAS 78782-99-7)
- 2,4,6-Tris(propan-2-yl)-n-(2,2,6,6-tetramethylpiperidin-4-yl)benzene-1-sulfonamide (CAS 300574-86-1)
- 2-(4-ethoxybenzyl)-1-diethylaminoethyl-5-isothiocyanatobenzimidazole 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyanato-1h-benzimidazole-1-ethanamine 2-[(4-ethoxyphenyl)methyl]-n,n-diethyl-5-isothiocyano-1h-benzimidazole-1-ethanamine 85951-65-1 BIT benzimidazole isothiocyanate, etonitazenyl isothiocyanate bit(bezimidazole isothiocyanate, etonita zenylisothiocyanate) etonitazenyl isothiocyanate (CAS 85951-65-1)
- 4-Fluoro-6-(fluoromethyl)pyrimidin-2-amine (CAS 92311-40-5)
- 3,5-Dimethylpiperidine (cis- and trans- mixture) (CAS 35794-11-7)
- 3-Amino-2-oxo-3,4-dihydroquinolin-1(2H)-yl dimethylcarbamate hydrochloride (CAS 1258545-29-7)
- Isothiazol-3-amine hydrochloride (CAS 1955506-86-1)
- 4-Benzyl-7-nitrobenzo[c][1,2,5]oxadiazole (CAS 143909-00-6)
- Fmoc-Ala-Gly-OH (CAS 116747-54-7)
- 2-methyl-2-(piperidin-3-yl)propanoic acid hydrochloride (CAS 1864072-88-7)
- rac-Nicotine (CAS 22083-74-5)
- 3-Amino-3-(2,3-dimethylphenyl)propanoic acid (CAS 412925-12-3)
- Semaglutide impurity 202 (CAS CATO-C4X-2226202)
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