Pyrimethamine EP Impurity D CAS 55474-41-4
| CAS No. | 55474-41-4 |
| Molecular Formula | C13H14ClNO2 |
| Molecular Weight | 251.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Pyrimethamine EP Impurity D (CAS 55474-41-4) is a certified pharmaceutical impurity reference standard with the molecular formula C13H14ClNO2 and a molecular weight of 251.71 g/mol.
Structurally, Pyrimethamine EP Impurity D (C13H14ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 251.71 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Pyrimethamine EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H14ClNO2 |
| Molecular Weight | 251.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Pyrimethamine Standards
- Pyrimethamine-D3 (CAS 1189936-99-9)
- Pyrimethamine (CAS 58-14-0)
- Pyrimethamine Impurity 1 (CAS 772-79-2)
- Pyrimethamine Impurity 4 (CAS 91284-15-0)
- Pyrimethamine N3-Oxide (CAS CATO-C4X-20441)
- Pyrimethamine Impurity 3 (CAS 3275-44-3)
- Pyrimethamine EP Impurity A (CAS 55474-40-3)
- Pyrimethamine EP Impurity C (CAS 140-53-4)
Recommended Standards
- Lornoxicam Impurity 31 (CAS CATO-C4X-201631)
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- Domperidone EP Impurity A (CAS 53786-28-0)
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