Betamethasone Impurity N25 CAS 5534-14-5
| CAS No. | 5534-14-5 |
| Molecular Formula | C26H35FO6 |
| Molecular Weight | 462.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Betamethasone Impurity N25.
Betamethasone Impurity N25 (CAS 5534-14-5) is a certified pharmaceutical impurity reference standard with the molecular formula C26H35FO6 and a molecular weight of 462.55 g/mol.
Owing to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution, Betamethasone Impurity N25 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 462.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Betamethasone Impurity N25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H35FO6 |
| Molecular Weight | 462.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Valerate EP Impurity I (CAS 2802-10-0)
- Betamethasone EP Impurity D (CAS 52619-05-3)
- Betamethasone Impurity 30 (CAS 52619-21-3)
- Betamethasone 17-Propionate-d5 (CAS CATO-C4X-143735)
- Betamethasone impurity 106 (CAS 330157-03-4)
- Betamethasone Impurity 42 (CAS 25122-45-6)
- Betamethasone impurity 103 (CAS CATO-C4X-1437103)
- Betamethasone Impurity 132 (CAS CATO-C4X-1437132)
Recommended Standards
- Ribociclib Impurity 9 (CAS 2460732-08-3)
- AGI5198 (CAS 1355326-35-0)
- Trilaciclib Impurity 16 (CAS CATO-C4X-304416)
- DDD107498, >98% (HPLC) (CAS 1469439-69-7)
- Dopamine Impurity 119 (CAS 24997-85-1)
- Piperidine Impurity 23 (CAS CATO-C4X-239923)
- Dapoxetine Impurity 73 (CAS CATO-C4X-143973)
- 4-Methoxy-2-(propan-2-yloxy)benzoic acid (CAS 79128-14-6)
- (2-Amino-3-(aminomethyl)-5-(difluoromethyl)pyridin-4-yl)methanol (CAS 1806006-00-7)
- 3,3-Diphenyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acrylonitrile (CAS 288105-07-7)
- Ethyl 4-hydroxybenzenecarboximidoate (CAS 79416-60-7)
- 7-Bromo-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridine-2-carboxylic acid (CAS 2733461-26-0)
- N-(1-amino-2-methylpropan-2-yl)acetamide (CAS 15543-78-9)
- Peptide Impurity 28 (CAS 1350456-64-2)
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