Pyrimethamine EP Impurity C CAS 140-53-4
| CAS No. | 140-53-4 |
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 151.59 g/mol gives Pyrimethamine EP Impurity C distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Pyrimethamine EP Impurity C (CAS 140-53-4, C8H6ClN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Pyrimethamine EP Impurity C (C8H6ClN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Pyrimethamine Standards
- Pyrimethamine Impurity 6 (CAS 2856-63-5)
- Pyrimethamine EP Impurity A (CAS 55474-40-3)
- Pyrimethamine Impurity 3 (CAS 3275-44-3)
- Pyrimethamine Impurity 1 (CAS 772-79-2)
- Pyrimethamine (CAS 58-14-0)
- Pyrimethamine EP Impurity D (CAS 55474-41-4)
- Pyrimethamine-D3 (CAS 1189936-99-9)
- Pyrimethamine Impurity 4 (CAS 91284-15-0)
Recommended Standards
- Letrozole Impurity 38 (CAS 874-86-2)
- Letrozole Impurity 30 (CAS 64407-07-4)
- 4-(chloromethyl)-3-fluoro-pyridine (CAS 1060802-36-9)
- Letrozole Impurity 29 (CAS 612-13-5)
- Fluphenazine Decanoate EP Impurity D (CAS 97671-70-0)
- Nateglinide EP Impurity C (CAS CATO-C4X-13209)
- Rebamipide impurity 03 (CAS 681806-75-7)
- 3-Methoxy-2-methylpropanal (CAS 13141-08-7)
- 4-Methyl-3-(4-methyl-1,3-oxazol-2-yl)aniline (CAS 1339691-72-3)
- Chloramphenicol closed-loop dimer1 (CAS CATO-C4X-232135)
- (6-formyl-3-hydroxy-2-methoxy-phenyl) acetate (CAS 272785-31-6)
- 3-amino-4-ethylbenzene-1-sulfonic acid (CAS 3694-83-5)
- n-(2-Aminoethyl)-4-methyl-2-oxo-2,3-dihydrothiazole-5-sulfonamide (CAS 1155139-93-7)
- Semaglutide impurity 73 (CAS CATO-C4X-222673)
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