Bromhexine Impurity 48 HCl CAS 5579-35-1
| CAS No. | 5579-35-1 |
| Molecular Formula | C8H10Br2N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Bromhexine Impurity 48 HCl is closely related to a nitrile group, chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Bromhexine Impurity 48 HCl (CAS 5579-35-1) is a certified pharmaceutical impurity reference standard with the molecular formula C8H10Br2N2HCl and a molecular weight of 330.45 g/mol.
Based on its molecular formula C8H10Br2N2HCl, Bromhexine Impurity 48 HCl contains a nitrile group, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 330.45 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Bromhexine Impurity 48 HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H10Br2N2 HCl |
| Molecular Weight | 330.45 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromhexine Standards
- Bromhexine Impurity 35 (CAS 100-60-7)
- Bromhexine impurity 59 (CAS 100669-81-6)
- Bromhexine Impurity 51 (CAS 100669-82-7)
- Bromhexine EP Impurity D(2HCl) (CAS 10076-98-9)
- Bromhexine Impurity 22 (CAS 114059-99-3)
- Bromhexine Impurity 17 (CAS 114390-40-8)
- Bromhexine Impurity N3 (CAS 114390-41-9)
- Bromhexine impurity 60 (CAS 1261676-18-9)
Recommended Standards
- Isavuconazole Impurity 195 (CAS CATO-C4X-1236195)
- Vazegepant impurity 35 (CAS CATO-C4X-320035)
- Crizotinib Impurity 53 (CAS CATO-C4X-102553)
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- D-Ala21-Tirzepatide (CAS CATO-CPTD788913)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com