Berberine Impurity 13 CAS 55971-02-3
| CAS No. | 55971-02-3 |
| Molecular Formula | C20H16NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 369.80 g/mol gives Berberine Impurity 13 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Berberine Impurity 13 (CAS 55971-02-3), a pharmacopoeial impurity reference standard (molecular formula C20H16NO4Cl, MW 369.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Berberine Impurity 13 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 369.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Berberine Impurity 13 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H16NO4 Cl |
| Molecular Weight | 369.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Berberine Standards
- Berberine Impurity 33 (CAS 100101-07-3)
- Berberine Impurity 15 Chloride (CAS 1186107-72-1)
- Berberine Chloride hydrate (CAS 141433-60-5)
- Berberine Impurity 31 (CAS 17388-19-1)
- Berberine Impurity 14 (CAS 2043361-62-0)
- Berberine (CAS 2086-83-1)
- Berberine Impurity 16 Chloride (CAS 2363741-22-2)
- Berberine Impurity 29 (CAS 2375597-30-9)
Recommended Standards
- Dopamine Impurity 12 HCl (CAS 101089-44-5)
- Atrasentan Impurity 75 (CAS 1058551-12-4)
- Progesterone Impurity 17 (CAS 2243-08-5)
- Ethyl 4-(2-Fluorophenyl)-2,4-dioxobutanoate (CAS 741286-80-6)
- 5-[1-(2-Chlorobenzenesulfonyl)pyrrolidin-2-yl]-3-(2-chlorophenyl)-1,2,4-oxadiazole (CAS 551931-01-2)
- 1-(Pyridin-2-ylsulfonyl)piperidin-3-amine hydrochloride (CAS 1353986-18-1)
- (E)-2-Ethylhex-2-enal (CAS 64344-45-2)
- Atracurium Impurity 44 (CAS CATO-C4X-185044)
- 2-(4-Allyl-5-((2-chlorobenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine (CAS 575461-53-9)
- Fibrinogen-Binding Peptide (CAS 137235-80-4)
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