Betamethasone Impurity 86 CAS 560-34-9
| CAS No. | 560-34-9 |
| Molecular Formula | C22H31FO5 |
| Molecular Weight | 394.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Betamethasone Impurity 86.
Betamethasone Impurity 86 (CAS 560-34-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H31FO5 and a molecular weight of 394.48 g/mol.
Based on its molecular formula C22H31FO5, Betamethasone Impurity 86 contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 394.48 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Betamethasone Impurity 86 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H31FO5 |
| Molecular Weight | 394.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Impurity 136 (CAS CATO-C4X-1437136)
- Betamethasone Impurity 38 (CAS 25121-04-4)
- Betamethasone impurity 65 (CAS CATO-C4X-143765)
- Betamethasone Impurity 22 (CAS 2990-65-0)
- Betamethasone EP Impurity H (CAS 185613-71-2)
- Betamethasone Impurity 117 (CAS CATO-C4X-1437117)
- Betamethasone Impurity 145 (CAS CATO-C4X-1437145)
- Betamethasone Impurity 34(Mixture of Diastereomers) (CAS 1249-19-0)
Recommended Standards
- Dexamethasone EP Impurity C (CAS 426-17-5)
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- Ethyl 2-((3-(4-fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)butanoate (CAS 687562-47-6)
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- Desogestrel (CAS 54024-22-5)
- N-([1,1'-Biphenyl]-2-yl)-2-((4-allyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 573935-42-9)
- 9-Ethyl-1-methyl-9H-pyrido[2,3-b]indol-1-ium iodide (CAS 59715-32-1)
- Tert-butyl 5-(aminomethyl)-3,3-dimethylpiperidine-1-carboxylate (CAS 1785324-09-5)
- Semaglutide impurity 196 (CAS CATO-C4X-2226196)
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