Oxazepam impurity 3 CAS 5628-03-5
| CAS No. | 5628-03-5 |
| Molecular Formula | C15H12ClNO3 |
| Molecular Weight | 289.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Oxazepam impurity 3 (C15H12ClNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 289.71 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Oxazepam impurity 3 (CAS 5628-03-5, C15H12ClNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12ClNO3 |
| Molecular Weight | 289.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Oxazepam Standards
Recommended Standards
- Bromfenac Impurity 72 (CAS 61941-63-7)
- Pranoprofen impurity 69 (CAS CATO-C4X-181169)
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- Pranoprofen Impurity 60 (CAS 111541-71-0)
- Darolutamide Impurity 43 (CAS CATO-C4X-310643)
- Doxofylline Impurity 33 (CAS CATO-C4X-151333)
- Tryptophan Impurity 18 (CAS CATO-C4X-137318)
- tert-Butyl (3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-3-hydroxypropyl)carbamate (CAS 865364-92-7)
- cis-3-Amino-1-methylcyclobutanol Hydrochloride (CAS 1523606-23-6)
- 1-(methoxymethyl)-3,5-dimethyl-1H-pyrazole-4-sulfonyl chloride (CAS 1803605-48-2)
- 2-Propenoic acid, polymer with 1,1-dimethylethyl 2-propenoate and ethene (CAS 25266-67-5)
- 9-Butyl-8-((3,4,5-trimethoxyphenyl)sulfinyl)-9H-purin-6-amine (CAS 827302-62-5)
- 2-Amino-N-cyclopropyl-N-(1-(pyrazin-2-yl)ethyl)acetamide (CAS 1353984-77-6)
- Tirzepatide (CAS 2023788-19-2)
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