Thioctic Acid Impurity 51 CAS 56535-97-8
| CAS No. | 56535-97-8 |
| Molecular Formula | C8H13ClO3 |
| Molecular Weight | 192.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Thioctic Acid Impurity 51 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Thioctic Acid Impurity 51 (CAS 56535-97-8, C8H13ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Thioctic Acid Impurity 51 (C8H13ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H13ClO3 |
| Molecular Weight | 192.64 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
Related Thioctic Standards
- Thioctic Acid Impurity 11 (CAS 1071-71-2)
- Thioctic acid Impurity 42 (CAS 90435-60-2)
- Thioctic Acid Impurity 52 (CAS CATO-C4X-152652)
- Thioctic acid impurity 62 (CAS 93892-06-9)
- Thioctic acid Impurity 79 (CAS 105986-59-2)
- Thioctic Acid Impurity 48 (CAS 2975-17-9)
- Thioctic Acid Impurity 50 (CAS CATO-C4X-152650)
- Thioctic acid Impurity 33 (CAS 50628-92-7)
Recommended Standards
- Methyl 2-acetyl-5-chloropentanoate (CAS 89118-13-8)
- Lercanidipine Impurity 69 (CAS CATO-C4X-136469)
- {7-chloro-[1,2,4]triazolo[4,3-c]pyrimidin-3-yl}methanol (CAS 1183462-18-1)
- Lercanidipine Impurity 57 (CAS CATO-C4X-136457)
- Salbutamol Impurity 211 (CAS CATO-C4X-1176211)
- Levosimendan Impurity 24 (CAS CATO-C4X-130824)
- Avatrombopag Impurity 67 (CAS 901314-75-8)
- 3-(5-(3,5-Bis(trifluoromethyl)phenyl)furan-2-yl)-1-(3,4-dichlorophenyl)prop-2-en-1-one (CAS 646497-86-1)
- cis-4-(Dimethylamino)cyclohexanol (CAS 103023-50-3)
- benzyl (2R,3R)-3-Amino-2-methylpiperidine-1-carboxylate (CAS 1044641-49-7)
- N-ethyl-6-(1H-pyrazol-1-yl)pyrimidin-4-amine (CAS 1340690-53-0)
- 4-(2-Mercapto-4,4-dimethylpyrimidin-1(4H)-yl)-3-methoxybenzoic acid (CAS 1142198-83-1)
- 3-(3-(3,6-Dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)thiazolidine-2,4-dione (CAS 312631-87-1)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788679)
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