Phenylephrine EP Impurity E CAS 56917-44-3
| CAS No. | 56917-44-3 |
| Molecular Formula | C16H17NO2 |
| Molecular Weight | 255.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Phenylephrine EP Impurity E is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Phenylephrine EP Impurity E (CAS 56917-44-3, C16H17NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H17NO2, Phenylephrine EP Impurity E contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 255.31 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17NO2 |
| Molecular Weight | 255.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Nitrogen Atoms | 1 |
Related Phenylephrine Standards
- Phenylephrine EP Impurity D Racemate (CAS 1159977-09-9)
- Phenylephrine Impurity 30 (CAS 286426-31-1)
- Phenylephrine EP Impurity D (CAS 1367567-95-0)
- Phenylephrine-3-O-Sulfate (CAS 1242184-39-9)
- Phenylephrine Impurity 10 (CAS 1391194-63-0)
- Phenylephrine Impurity 11 (CAS 1391194-51-6)
- Phenylephrine Impurity 52 (CAS 1785420-81-6)
- Phenylephrine Impurity 9 (CAS 1391194-66-3)
Recommended Standards
- O2-tert-butyl O3-ethyl (1R,3R,5R)-2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate (CAS 871727-37-6)
- p-Tolyl-p-tolylamino-acetic acid (CAS 725252-92-6)
- N-Ethyl-2-methoxy-N-phenylbenzamide (CAS 947823-85-0)
- rel-((4aR,8aR)-tert-Butyl 4-oxohexahydro-2H-pyrano[3,2-c]pyridine-6(7H)-carboxylate) (CAS 2177266-88-3)
- Rivaroxaban Impurity 45 (CAS 6310-09-4)
- Bicalutamide Impurity 37 (CAS CATO-C4X-101337)
- Difelikefalin Impurity 14 (CAS 2742623-84-1)
- 2-(3-Aminobenzenesulfonamido)acetamide (CAS 953751-81-0)
- 4-((2,3-Dihydro-1H-inden-5-yl)oxy)-3-fluoroaniline (CAS 937598-03-3)
- 1-(2,4-Dichlorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol (CAS 125240-57-5)
- 1,4-Naphthalenedicarboxylic Acid (CAS 605-70-9)
- Hydroxy-PEG1-acid (CAS 89211-34-7)
- Methyl ((S)-1-((2S,4R)-2-(((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)carbamoyl)-4-(trifluoromethyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate (CAS 2755812-39-4)
- Heptapeptide-6 (CAS CATO-CPTD788823)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com