Miconazole Impurity 24 CAS 57432-78-7
| CAS No. | 57432-78-7 |
| Molecular Formula | C12H12Cl2N2O |
| Molecular Weight | 271.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Miconazole Impurity 24 (CAS 57432-78-7, C12H12Cl2N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Miconazole Impurity 24 (C12H12Cl2N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Miconazole Impurity 24 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12Cl2N2O |
| Molecular Weight | 271.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Miconazole Standards
- Miconazole Impurity 30 (CAS CATO-C4X-180230)
- Miconazole Impurity 31 (CAS CATO-C4X-180231)
- Miconazole EP Impurity H (CAS 181931-30-6)
- Miconazole EP Impurity C (CAS 67358-54-7)
- Miconazole Impurity 15 (CAS 913837-72-6)
- Miconazole EP Impurity I (CAS 47363-37-1)
- Miconazole Impurity N1 (CAS 911805-54-4)
- Miconazole EP Impurity D (CAS 27523-40-6)
Recommended Standards
- Sertaconazole EP Impurity A (CAS CATO-C4X-10751)
- PBT 1033 (CAS 747408-78-2)
- 5,6-Dichloro-2'-methyl-spiro[indoline-3,4'-pyrrolidine]-2-one (CAS 2874373-76-7)
- 5-Bromo-2-((1-methylpiperidin-4-yl)oxy)pyridine (CAS 1015242-41-7)
- Chlorprothixene EP Impurity A (CAS 4295-65-2)
- Tulathromycin A Impurity 4 (CAS CATO-C4X-21075)
- Ivabradine Impurity 14 (CAS CATO-C4X-111914)
- 4-(4-Chlorophenoxy)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (CAS 6289-05-0)
- Lobeglitazone-d3 (CAS CATO-CCAD304333)
- 2-(6-Chloro-7-hydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetic acid (CAS 855287-83-1)
- 1-(Phenylsulfonyl)-1H-indole-3-carboxylic acid (CAS 278593-17-2)
- 1-(2,3-Dichlorophenyl)-1H-pyrrole-2-carbaldehyde (CAS 383135-89-5)
- 2-Chloro-n-(5-fluoro-2-methylphenyl)propanamide (CAS 1017026-21-9)
- [y-Glu3]-Semaglutide Impurity 135 (CAS CATO-C4X-2226135)
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