Miconazole EP Impurity D CAS 27523-40-6
| CAS No. | 27523-40-6 |
| Molecular Formula | C18H14Cl4N2O |
| Molecular Weight | 416.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Miconazole EP Impurity D (CAS 27523-40-6), a pharmacopoeial impurity reference standard (molecular formula C18H14Cl4N2O, MW 416.13 g/mol) used for the identification and quantification of trace impurities in APIs.
Miconazole EP Impurity D (C18H14Cl4N2O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H14Cl4N2O |
| Molecular Weight | 416.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Miconazole Standards
- Miconazole EP Impurity F (CAS 47447-55-2)
- Miconazole EP Impurity G (CAS 909277-71-0)
- Miconazole (CAS 22916-47-8)
- Miconazole impurity 34 (CAS CATO-C4X-180234)
- Miconazole Impurity N1 (CAS 911805-54-4)
- Miconazole Impurity 15 (CAS 913837-72-6)
- Miconazole EP Impurity I (CAS 47363-37-1)
- Miconazole EP Impurity C (CAS 67358-54-7)
Recommended Standards
- (S)-1-(2-((2,4-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole (CAS 47447-52-9)
- (R)-1-(2-((2,4-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole (CAS 47447-53-0)
- Dibutyl 2,3,4,5-Tetrachlorophthalate (CAS 3015-66-5)
- 2-(2-Bromophenyl)-5-((2,6-dichlorobenzyl)thio)-1,3,4-oxadiazole (CAS 444157-02-2)
- Vericiguat Impurity 101 (CAS 1374344-58-7)
- Metoprolol Impurity 18 (CAS 56718-70-8)
- Venetoclax Impurity 148 (CAS CATO-C4X-2495148)
- 4-Oxobenzofuro[3,2-d]pyrimidine-3(4H)-acetic acid (CAS 257613-44-8)
- Ethyl 5-chloro-8-fluoro-4-hydroxyquinoline-3-carboxylate (CAS 1019015-59-8)
- 3-(tert-Butoxy)-5-(trifluoromethyl)phenol (CAS 1243450-56-7)
- 4-Ethoxypyridine 1-oxide (CAS 14474-56-7)
- 5-Bromo-8-fluoroquinolin-4-ol (CAS 1065092-39-8)
- Pentachloroaniline (CAS 527-20-8)
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com