Imatinib EP Impurity B CAS 581076-65-5
| CAS No. | 581076-65-5 |
| Molecular Formula | C21H28N6O |
| Molecular Weight | 380.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Imatinib EP Impurity B (C21H28N6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 380.49 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Imatinib EP Impurity B (CAS 581076-65-5, C21H28N6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Imatinib EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H28N6O |
| Molecular Weight | 380.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 6 |
Related Imatinib Standards
- Imatinib Impurity 95 (CAS 1642630-12-3)
- Imatinib Impurity 97 (CAS CATO-C4X-106897)
- Imatinib Impurity 50 (CAS CATO-C4X-106850)
- Imatinib Impurity 96 (CAS 152459-96-6)
- Imatinib Impurity 95 (CAS CATO-C4X-106895)
- Imatinib Impurity 89 (CAS CATO-C4X-106889)
- Imatinib Impurity 47 (CAS CATO-C4X-106847)
- Imatinib Impurity 83 (CAS 1206604-20-7)
Recommended Standards
- N-(Benzo[d]thiazol-2-yl)-2-((1-(m-tolyl)-1H-imidazol-2-yl)thio)acetamide (CAS 851131-17-4)
- 1242901-41-2 4-(4-Methylpiperidin-1-yl)-3-[(4-methylpiperidin-1-yl)sulfonyl]benzoic acid MFCD15732184 (CAS 1242901-41-2)
- N-(5-((2-((Furan-2-ylmethyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide (CAS 868972-94-5)
- 2-((1-(Thiophen-2-ylsulfonyl)piperidin-4-yl)oxy)benzo[d]thiazole (CAS 1251577-30-6)
- Streptomycin impurity 2 (CAS CATO-C4X-22712)
- Methotrexate Impurity 64 (CAS 52980-66-2)
- Ponatinib Impurity 2 (CAS CATO-C4X-22692)
- 2-(1-Isobutylpiperidin-3-yl)acetic acid (CAS 1220019-60-2)
- 5-Ethyl-1,3,4-thiadiazole-2-carbaldehyde (CAS 2044797-24-0)
- Methyl 6-bromo-2-fluoro-3-methoxybenzoate (CAS 1007455-28-8)
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- 2-Bromo-4-chloro-5-(difluoromethyl)-3-methoxypyridine (CAS 1805373-16-3)
- Acetyl Tetrapeptide-11 (CAS 928006-88-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com