Rosuvastatin Impurity 252 CAS 587855-03-6

Description

Compared with other compounds in its class, the molecular weight of 180.59 g/mol gives Rosuvastatin Impurity 252 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Rosuvastatin Impurity 252 (CAS 587855-03-6), a pharmacopoeial impurity reference standard (molecular formula C6H9ClO4, MW 180.59 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Rosuvastatin Impurity 252 (C6H9ClO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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