Rosuvastatin Impurity 253 CAS 958358-67-3
| CAS No. | 958358-67-3 |
| Molecular Formula | C6H11ClO4 |
| Molecular Weight | 182.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Rosuvastatin Impurity 253 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Rosuvastatin Impurity 253 (CAS 958358-67-3), a pharmacopoeial impurity reference standard (molecular formula C6H11ClO4, MW 182.60 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Rosuvastatin Impurity 253 (C6H11ClO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 1.0, corresponding to approximately 1 ring(s) or double-bond equivalent(s). With a molecular weight of 182.60 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H11ClO4 |
| Molecular Weight | 182.60 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 216 (CAS 65372-09-0)
- Rosuvastatin Impurity 252 (CAS 587855-03-6)
- Rosuvastatin Impurity 197 (CAS 727382-14-1)
- Rosuvastatin Impurity 198 (CAS 5292-43-3)
- Rosuvastatin Impurity 32 (CAS 123185-88-6)
- Rosuvastatin Impurity 33 (CAS CATO-C4X-116933)
- Rosuvastatin Impurity 9 (CAS CATO-C4X-11699)
- Rosuvastatin Impurity 90 (CAS 934-34-9)
Recommended Standards
- Baclofen impurity 19 (CAS 940-62-5)
- Bupropion Impurity 17 (CAS 10557-17-2)
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