Avanafil Impurity 55 CAS 5909-24-0
| CAS No. | 5909-24-0 |
| Molecular Formula | C8H9ClN2O2S |
| Molecular Weight | 232.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Avanafil Impurity 55.
Avanafil Impurity 55 (CAS 5909-24-0) is a certified pharmaceutical impurity reference standard with the molecular formula C8H9ClN2O2S and a molecular weight of 232.69 g/mol.
Avanafil Impurity 55 (C8H9ClN2O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9ClN2O2S |
| Molecular Weight | 232.69 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Avanafil Standards
- Avanafil Impurity 108 (CAS CATO-C4X-1118108)
- Avanafil Impurity 111 (CAS CATO-C4X-1118111)
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- Avanafil Impurity 160 (CAS 1202002-16-1)
- Avanafil Impurity 109 (CAS CATO-C4X-1118109)
- Avanafil Impurity 70 (CAS 32897-26-0)
Recommended Standards
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- 2881-63-2 3-(4-Chlorophenyl)-3-oxopropanoic acid ethyl ester Ethyl (4-chlorobenzoyl)acetate Ethyl 3-(4-chlorophenyl)-3-oxopropanoate NSC 406743 (CAS 2881-63-2)
- Moxonidine impurity 4 (CAS CATO-C4X-27814)
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- Pyridoxine impurity 4 (CAS 913696-26-1)
- 1-(4-Hydroxy-3,5-dimethylphenyl)-2-(4-methylbenzenesulfonyl)ethan-1-one (CAS 344280-00-8)
- 2-(2-(Tert-butyl)phenoxy)acetonitrile (CAS 202821-16-7)
- N-methyl-4-(piperazin-1-ylmethyl)aniline (CAS 954240-22-3)
- Tert-butyl ((1R,2S)-2-cyanocyclopropyl)carbamate (CAS 2165452-13-9)
- 4-Methoxy-3,3-dimethylbutan-1-amine (CAS 854417-06-4)
- 4-fluoro-7-nitro-1H-indole (CAS 1167056-95-2)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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