Codeine hydrochloride dihydrate CRS - * narc CAS 5916-29-0
| CAS No. | 5916-29-0 |
| Molecular Formula | C18H21NO3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Codeine hydrochloride dihydrate CRS - * narc meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Codeine hydrochloride dihydrate CRS - * narc (CAS 5916-29-0), molecular formula C18H21NO3HClH2O and molecular weight 353.84 g/mol, is a CATO reference standard with documented purity and traceability.
Codeine hydrochloride dihydrate CRS - * narc (C18H21NO3HClH2O) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C18H21NO3 HCl 2*H2O |
| Molecular Weight | 353.84 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Codeine Standards
- Codeine-D6 (CAS 1007844-34-9)
- codeine hydrochloride (CAS 1422-07-7)
- Codeine β-D-Glucuronide Triacetate Methyl Ester (1.0mg/ml in Acetonitrile) (CAS 20736-10-1)
- Codeine-6β-D-glucuronide (CAS 20736-11-2)
- Codeine-6-ß-D-glucuronide-D3 (CAS 219533-59-2)
- Codeine 6-Methanesulfonate (1.0mg/ml in Acetonitrile) (CAS 22952-80-3)
- Codeine EP Impurity A (CAS 2859-16-7)
- Codeine Phosphate CII (1144000) (CAS 41444-62-6)
Recommended Standards
- 3-Aminoquinoline-8-carboxylic acid (CAS 1799412-39-7)
- N-(2-methyl-1H-benzo[d]imidazol-6-yl)acetamide (CAS 56842-62-7)
- 2,5-Dichloro-4-(trimethylstannyl)pyridine (CAS 1201787-84-9)
- 8-Methoxyquinoline-6-carbonitrile (CAS 1378775-88-2)
- Methyl 3-(4-hydroxyphenyl)propiolate (CAS 136634-54-3)
- 1-Methyl-1H-benzo[d][1,2,3]triazole-4-sulfonyl chloride (CAS 1033464-77-5)
- 2,3-Dibromo-7,8-dihydrodioxino-dibenzodioxin (CAS 782471-80-1)
- 4-Bromo-2-fluoroaniline (CAS 367-24-8)
- 6-(Difluoromethyl)-5-fluoro-3-(trifluoromethyl)picolinonitrile (CAS 1804712-89-7)
- Semaglutide impurity 229 (CAS CATO-C4X-2226229)
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