Midazolam EP Impurity B CAS 59469-74-8
| CAS No. | 59469-74-8 |
| Molecular Formula | C18H13ClFN3 |
| Molecular Weight | 325.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Midazolam EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Midazolam EP Impurity B (CAS 59469-74-8), a pharmacopoeial impurity reference standard (molecular formula C18H13ClFN3, MW 325.77 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C18H13ClFN3, Midazolam EP Impurity B contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 325.77 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H13ClFN3 |
| Molecular Weight | 325.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- 【禁售不询】Midazolam (CAS 59467-70-8)
- Midazolam Impurity 28 (CAS CATO-C4X-150928)
- Midazolam EP Impurity A (CAS 59468-07-4)
- Midazolam Impurity 40 (CAS CATO-C4X-150940)
- Midazolam EP Impurity J (CAS 59469-08-8)
- Midazolam-d5 (Major) Discontinued See M343003 (CAS 395067-42-2)
- Midazolam Impurity 23 (CAS CATO-C4X-150923)
- Midazolam Impurity 25 (CAS CATO-C4X-150925)
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- 4-Bromo-1,2-diiodobenzene (CAS 21521-54-0)
- Gadodiamide EP Impurity B Disodium Salt (CAS 92923-64-3)
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