Midazolam Hydrochloride CAS 59467-96-8
| CAS No. | 59467-96-8 |
| Molecular Formula | C18H14Cl2FN3 |
| Molecular Weight | 362.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Midazolam Hydrochloride (CAS 59467-96-8), molecular formula C18H14Cl2FN3 and molecular weight 362.22 g/mol, is a CATO reference standard with documented purity and traceability.
Midazolam Hydrochloride (C18H14Cl2FN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Midazolam Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H14Cl2FN3 |
| Molecular Weight | 362.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam 2,5-Dioxide-d6 (CAS 1215321-98-4)
- Midazolam Impurity 19 (CAS CATO-C4X-150919)
- Midazolam Impurity 18 (CAS CATO-C4X-150918)
- Midazolam Impurity 20 (CAS 151921-06-1)
- Midazolam Impurity 35 (CAS CATO-C4X-150935)
- Midazolam Impurity 34 (CAS CATO-C4X-150934)
- Midazolam 2-Oxide (CAS 59468-86-9)
- Midazolam EP Impurity C (CAS 59468-44-9)
Recommended Standards
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- Aztreonam Impurity 18 (CAS CATO-C4X-152218)
- Chloroacetamido-PEG4-C2-Boc (CAS 1365655-90-8)
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- (Z,Z)-1,3-Diiminoisoindoline (CAS 160956-25-2)
- ((1-Bromocyclopropyl)ethynyl)triethylsilane (CAS 2137817-20-8)
- 1-(2,2,2-Trifluoroethoxymethyl)-cyclopropanecarboxylic acid (CAS 1698705-02-0)
- Eledoisin Related Peptide (CAS 2990-43-4)
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