Midazolam EP Impurity A CAS 59468-07-4
| CAS No. | 59468-07-4 |
| Molecular Formula | C18H15ClFN3 |
| Molecular Weight | 327.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C18H15ClFN3, Midazolam EP Impurity A contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 327.78 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Midazolam EP Impurity A (CAS 59468-07-4, C18H15ClFN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Midazolam EP Impurity A under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H15ClFN3 |
| Molecular Weight | 327.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam Impurity 28 (CAS CATO-C4X-150928)
- 【禁售不询】Midazolam (CAS 59467-70-8)
- Midazolam EP Impurity B (CAS 59469-74-8)
- Midazolam Impurity 40 (CAS CATO-C4X-150940)
- Midazolam EP Impurity J (CAS 59469-08-8)
- Midazolam-d5 (Major) Discontinued See M343003 (CAS 395067-42-2)
- Midazolam Impurity 25 (CAS CATO-C4X-150925)
- Midazolam Impurity 23 (CAS CATO-C4X-150923)
Recommended Standards
- Ethyl 2-[(chloroacetyl)amino]-4-(5-methyl-2-furyl)thiophene-3-carboxylate (CAS 736960-88-6)
- 8-Chloro-6-(2-fluorophenyl)-1-methyl-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine (CAS 59467-69-5)
- 3-[(4-Chloro-3-fluorophenyl)amino]-1-(naphthalen-2-yl)propan-1-one (CAS 939888-37-6)
- 2-Chloro-N-(3-(6-oxopyridazin-1(6H)-yl)propyl)benzenesulfonamide (CAS 1105234-53-4)
- Aclidinium bromide Impurity 2 (CAS 7333-07-5)
- Dotinurad Impurity 194 (CAS 50910-60-6 (free base))
- Mycophenolate Impurity 22 (CAS CATO-C4X-151522)
- Benzyl (4aS,7aS)-7-oxo-octahydro-1H-cyclopenta[c]pyridine-2-carboxylate (CAS 140211-07-0)
- N-((3-phenylisoxazol-5-yl)methyl)acetamide (CAS 13608-58-7)
- 1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (CAS 1956369-32-6)
- 3-Iodo-2-methyl-5-nitropyridine (CAS 911434-20-3)
- 7-tert-butylazepan-2-one (CAS 155204-32-3)
- 5-[2,5-Bis(4-fluorophenyl)-3-thienyl]-1H-tetrazole (CAS 908849-28-5)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com