Midazolam Impurity 19 CAS CATO-C4X-150919

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-150919
Molecular FormulaC18H13ClFN2O3
Molecular Weight359.76 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Midazolam Impurity 19 CAS CATO-C4X-150919 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 359.76 g/mol gives Midazolam Impurity 19 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Midazolam Impurity 19 (CAS CATO-C4X-150919) is a certified pharmaceutical impurity reference standard with the molecular formula C18H13ClFN2O3 and a molecular weight of 359.76 g/mol.

Midazolam Impurity 19 (C18H13ClFN2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Midazolam Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC18H13ClFN2O3
Molecular Weight359.76 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity>95%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)12.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentF/Cl-containing
Nitrogen Atoms2

Related Midazolam Standards

Recommended Standards

Why CATO?