Droperidol EP Impurity C CAS 60373-76-4
| CAS No. | 60373-76-4 |
| Molecular Formula | C22H19FN3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 411.86 g/mol gives Droperidol EP Impurity C distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Droperidol EP Impurity C (CAS 60373-76-4) is a certified pharmaceutical impurity reference standard with the molecular formula C22H19FN3O2Cl and a molecular weight of 411.86 g/mol.
Structurally, Droperidol EP Impurity C (C22H19FN3O2Cl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 411.86 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Droperidol EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H19FN3O2 Cl |
| Molecular Weight | 411.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Droperidol Standards
- Droperidol EP Impurity B (CAS 1026015-45-1)
- Droperidol EP Impurity B HCl (CAS 1026015-45-1 (free base))
- Droperidol EP Impurity E (CAS 1346604-17-8)
- Droperidol EP Impurity E HCl (CAS 1346604-17-8 (free base))
- Droperidol EP Impurity A (CAS 2147-83-3)
- Droperidol Impurity 4 (CAS 25551-59-1)
- Droperidol Impurity 12 (CAS 3308-94-9)
- Droperidol Impurity 16 (CAS 39146-45-7)
Recommended Standards
- Lansoprazole Impurity 34 (CAS 1357726-93-2)
- Lifitegrast Impurity 145 (CAS CATO-C4X-2409145)
- Bimatoprost Impurity 11 (CAS CATO-C4X-196411)
- Fmoc-Dap(Dde)-OH (CAS 247127-51-1)
- N-Isopropylhydroxylamine (CAS 5080-22-8)
- 2-((3-Phenylpropyl)amino)quinazolin-4(1H)-one (CAS 61741-44-4)
- 1H-Imidazol-2-ylmethanol;hydrochloride (CAS 116177-22-1)
- (S)-2-amino-N-cyclopropyl-N-(4-fluorobenzyl)propanamide (CAS 1292746-34-9)
- 6-Methyl-1,4-dihydro-2,7-naphthyridin-3(2H)-one (CAS 1393585-29-9)
- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
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