Droperidol Impurity 12 CAS 3308-94-9
| CAS No. | 3308-94-9 |
| Molecular Formula | C12H14ClFO2 |
| Molecular Weight | 244.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Droperidol Impurity 12 (C12H14ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Droperidol Impurity 12 (CAS 3308-94-9) is a certified pharmaceutical impurity reference standard with the molecular formula C12H14ClFO2 and a molecular weight of 244.69 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Droperidol Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H14ClFO2 |
| Molecular Weight | 244.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Droperidol Standards
- Droperidol Impurity 18 (CAS CATO-C4X-276918)
- Droperidol Impurity 6 (CAS 41276-30-6)
- Droperidol Impurity 16 (CAS 39146-45-7)
- Droperidol EP Impurity A (CAS 2147-83-3)
- Droperidol Impurity 13 (CAS CATO-C4X-276913)
- Droperidol Impurity 4 (CAS 25551-59-1)
- Droperidol Impurity 14 (CAS 60172-08-9)
- Droperidol Impurity 5 (CAS 65053-26-1)
Recommended Standards
- But-3-yn-1-yl 4-chlorobenzenesulfonate (CAS 877171-15-8)
- 6-Chloro-4-ethoxy-3-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1037479-54-1)
- 4-(3-Chloropropyl)-4-(4-fluorophenyl)-1,3-dioxolane (CAS 55396-00-4)
- 3-Chloro-4-ethyl-4H-1,2,4-benzothiadiazin-1,1-dioxide (CAS 107089-77-0)
- Ramelteon Impurity 6（Cis-trans isomerism mixture） (CAS CATO-C4X-26226)
- Mirogabalin Impurity 11 (CAS CATO-C4X-292411)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
- Rosuvastatin Impurity 131 (CAS 1246665-85-9)
- 5-{2-azaspiro[3.3]heptan-2-yl}pyridin-2-amine (CAS 1509129-83-2)
- 2,2,2-Trifluoroethyl N-({4-[(4-methoxyphenyl)carbamoyl]phenyl}methyl)carbamate (CAS 477857-90-2)
- 2-(Tert-butyl)-6-(2-hydroxy-5-methylbenzyl)-4-methylphenol (CAS 81910-71-6)
- 2-Chloro-5-hydrazinyl-3,6-diphenylpyrazine (CAS 887571-68-8)
- 2-(Cyclopropylmethoxy)-3,3,3-trifluoropropan-1-amine (CAS 1157932-10-9)
- [3-31]-Semaglutide D (CAS C152H230N42O47)
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