Droperidol Impurity 16 CAS 39146-45-7
| CAS No. | 39146-45-7 |
| Molecular Formula | C15H18FNO2 |
| Molecular Weight | 263.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Droperidol Impurity 16 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 263.31 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Droperidol Impurity 16 (CAS 39146-45-7) is a certified pharmaceutical impurity reference standard with the molecular formula C15H18FNO2 and a molecular weight of 263.31 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H18FNO2 |
| Molecular Weight | 263.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Droperidol Standards
- Droperidol Impurity 6 (CAS 41276-30-6)
- Droperidol Impurity 12 (CAS 3308-94-9)
- Droperidol Impurity 18 (CAS CATO-C4X-276918)
- Droperidol Impurity 7 (CAS 60373-71-9)
- Droperidol EP Impurity A (CAS 2147-83-3)
- Droperidol Impurity 13 (CAS CATO-C4X-276913)
- Droperidol Impurity 4 (CAS 25551-59-1)
- Droperidol Impurity 14 (CAS 60172-08-9)
Recommended Standards
- Cilastatin EP Impurity E (CAS 1174657-07-8)
- 3-Amino-4-methoxy-n-(4-methyl-1,3-thiazol-2-yl)benzamide (CAS 1016741-33-5)
- Nimesulide EP Impurity B (CAS 51765-51-6)
- 3-(5-Oxo-1-phenyl-2-thioxoimidazolidin-4-yl)propanamide (CAS 10567-86-9)
- Sitagliptin Impurity 2 (CAS 769195-20-2)
- Iopromide impurity 14 (CAS CATO-C4X-183214)
- Epalrestat Impurity 6 (CAS 124782-63-4)
- n-(2-Phenyl-2h-1,2,3-triazol-4-yl)methanesulfonamide (CAS 1250430-95-5)
- 6-Cyclopropylpyridin-2-amine, 97% (CAS 857292-66-1)
- 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-1,2,4-triazole (CAS 2246885-44-7)
- 2-methylcyclobutan-1-amine (CAS 89381-05-5)
- 6-Bromo-2-chloro-3-methylphenol (CAS 1226808-67-8)
- 2-((2,6-Dinitro-4-(trifluoromethyl)phenyl)thio)benzoic acid (CAS 400066-32-2)
- Semaglutide impurity 248 (CAS CATO-C4X-2226248)
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