Progesterone Impurity 15 CAS 604-20-6
| CAS No. | 604-20-6 |
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Progesterone Impurity 15 (C21H30O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Progesterone Impurity 15 (CAS 604-20-6, C21H30O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H30O3 |
| Molecular Weight | 330.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Progesterone Standards
- Progesterone Impurity 19 (CAS 16031-66-6)
- Progesterone Impurity 9 (CAS 641-80-5)
- Progesterone Impurity 16 (CAS 604-19-3)
- Progesterone Impurity 83 (CAS CATO-C4X-150283)
- Progesterone Impurity N2 (CAS 40736-33-2)
- Progesterone Impurity 34 (CAS 60966-36-1)
- Progesterone Impurity 84 (CAS 66512-11-6)
- (20R)-Progesterone EP Impurity I (CAS 66289-21-2)
Recommended Standards
- Loxoprofen impurity 136 (CAS CATO-C4X-1488136)
- Medroxyprogesterone impurity 9 (CAS 14510-23-7)
- 17β-Hydroxyprogesterone (CAS 604-09-1)
- Testosterone Impurity 13 (CAS CATO-C4X-132613)
- Clopidogrel Impurity 31 (CAS 19995-38-1)
- Gemcitabine Impurity 26 (CAS 122111-12-0)
- Minodronic Impurity 32 (CAS 4628-68-6)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide (CAS 1257553-74-4)
- 2-Phenylthiophene-3-sulphonyl chloride (CAS 166964-12-1)
- 2,3-Dimethyl-4,6-dinitroaniline (CAS 147622-43-3)
- 6-Amino-7-((4-chlorophenyl)sulfonyl)-5-(4-ethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile (CAS 691396-68-6)
- 6-Chloro-3-(1-isopropylpyrrolidin-2-yl)-2-methylpyridine (CAS 1352519-26-6)
- Ethyl 5-bromo-1-methyl-1H-indole-2-carboxylate (CAS 91844-20-1)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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