(20R)-Progesterone EP Impurity I CAS 66289-21-2
| CAS No. | 66289-21-2 |
| Molecular Formula | C22H32O2 |
| Molecular Weight | 328.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (20R)-Progesterone EP Impurity I (CAS 66289-21-2), a pharmacopoeial impurity reference standard (molecular formula C22H32O2, MW 328.49 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, a hydroxyl group, an ether linkage, (20R)-Progesterone EP Impurity I is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 328.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), (20R)-Progesterone EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H32O2 |
| Molecular Weight | 328.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
Related R Standards
- Progesterone Impurity N5 (CAS 35525-27-0)
- Progesterone Impurity N1(Mixture of Diastereomers) (CAS 71658-22-5)
- Progesterone EP Impurity I (S-isomer) (CAS 3986-89-8)
- Progesterone EP Impurity I (CAS 24254-01-1)
- Progesterone Impurity 43 (CAS CATO-C4X-150243)
- Progesterone Impurity 45 (CAS CATO-C4X-150245)
- Progesterone Impurity 51 (CAS 103858-15-7)
- Progesterone Impurity 53 (CAS 903-03-7)
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