Edaravone Impurity N1 CAS 6078-46-2
| CAS No. | 6078-46-2 |
| Molecular Formula | C12H16N2O2 |
| Molecular Weight | 220.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Edaravone Impurity N1 (CAS 6078-46-2, C12H16N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Edaravone Impurity N1 (C12H16N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Edaravone Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16N2O2 |
| Molecular Weight | 220.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Edaravone Standards
- Edaravone Impurity 12 (CAS 2061958-41-4)
- Edaravone impurity 32 (CAS 852539-02-7)
- Edaravone impurity 47 (CAS 53341-66-5)
- Edaravone impurity 50 (CAS CATO-C4X-106250)
- Edaravone Impurity N3 (CAS 27301-70-8)
- Edaravone impurity 03 (CAS 114138-50-0)
- Edaravone impurity 1 (CAS 49597-17-3)
- Edaravone Impurity 28 (CAS 53855-47-3)
Recommended Standards
- Domperidone Impurity 4 (CAS 79923-70-9)
- Eltoprazine (CAS 98224-03-4)
- Dibenzo[a,e][8]annulen-5(6H)-one (CAS 3111-86-2)
- Ethyl (2Z)-3-(dimethylamino)-2-(pyridin-2-yl)prop-2-enoate (CAS 24403-31-4)
- Etelcalcetide Impurity 24 X TFA Salt (CAS CATO-C4X-324724)
- Tamoxifen impurity 19 (CAS CATO-C4X-123319)
- Voriconazole Impurity 31 (CAS 1157981-64-0)
- 7-(Difluoromethyl)-2,5-dimethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (CAS 869943-15-7)
- Methyl 3-amino-4-(benzyloxy)benzoate (CAS 927802-57-1)
- Octahydrocyclopenta[c]pyrrole-5-carbonitrile (CAS 1379162-31-8)
- n-(2-Bromo-4-fluorophenyl)-2-(2-oxopyrrolidin-1-yl)acetamide (CAS 1094384-58-3)
- (E)-5-Benzylidene-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one (CAS 304889-84-7)
- 4-Bromo-6-oxo-1,6-dihydropyridine-3-carbonitrile (CAS 1630193-35-9)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
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