Flurbiprofen Impurity 129 CAS 61467-16-1
| CAS No. | 61467-16-1 |
| Molecular Formula | C17H15FO4 |
| Molecular Weight | 302.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Flurbiprofen Impurity 129 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Flurbiprofen Impurity 129 (CAS 61467-16-1, C17H15FO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Flurbiprofen Impurity 129 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 302.30 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flurbiprofen Impurity 129 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H15FO4 |
| Molecular Weight | 302.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 13 (CAS CATO-C4X-144413)
- Flurbiprofen Impurity 140 (CAS 1531637-33-8)
- Flurbiprofen Impurity 148 (CAS CATO-C4X-1444148)
- Flurbiprofen Impurity 149 (CAS CATO-C4X-1444149)
- Flurbiprofen Impurity 141 (CAS 486455-73-6)
- Flurbiprofen Impurity 153 (CAS CATO-C4X-1444153)
- Flurbiprofen Impurity 170 (CAS 945721-92-6)
- Flurbiprofen Impurity 91 (CAS CATO-C4X-144491)
Recommended Standards
- 5-(Diphenylphosphinyl)pentanoic Acid (CAS 71140-70-0)
- 3700-89-8 Butanedioic acid, ((dimethoxyphosphinothioyl)thio)-, dimethyl ester (9CI) Phosphorodithioic acid, S-(1,2-dimethoxycarbonyl)ethyl O,O-dimethyl ester 4-03-00-01135 (Beilstein Handbook Reference) BRN 1802414 Carbomethoxy malathion S-(1,2-Dimethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate O,O-Dimethyl S-(1,2-dicarbomethoxy)ethyl phosphorodithioate O,O-Dimethyl malathion Phosphorodithioic acid, O,O-dimethyl ester,S-ester with 1,2-bis(methoxycarbonyl)ethanethiol Succinic acid, mercapto-, dimethyl ester, O,O-dimethyl phosphorodithioate Take 20 (CAS 3700-89-8)
- Malathion monocarboxylic acid (CAS 35884-76-5)
- Z-b-sulfamoyl-L-Ala-OH (CAS 33662-45-2)
- Vonoprazan Impurity 113 (CAS 1956309-28-6)
- Barnidipine Impurity 1 (CAS CATO-C4X-27561)
- Lumateperone Impurity 31 (CAS 313369-33-4)
- Z422836G9D 7790-87-6 Cerous iodide Cerium triiodide EINECS 232-228-3 UNII-Z422836G9D (CAS 7790-87-6)
- 4-Chloro-3-(3-methyl-1,2,4-oxadiazol-5-yl)aniline (CAS 1178338-36-7)
- 5-Methyl-1H-indol-7-amine (CAS 90868-10-3)
- Roxadustat Impurity 16 (CAS CATO-C4X-221316)
- Lopinavir EP Impurity F (CAS CATO-C4X-16826)
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- Mast Cell Degranulating Peptide HR-1 (CAS 80533-94-4)
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