N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide CAS 618427-88-6
| CAS No. | 618427-88-6 |
| Molecular Formula | C21H19ClF3N3O2S2 |
| Molecular Weight | 501.97 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide.
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 618427-88-6) is a high-purity analytical reference standard with the molecular formula C21H19ClF3N3O2S2 and a molecular weight of 501.97 g/mol.
The molecular framework of N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (C21H19ClF3N3O2S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H19ClF3N3O2S2 |
| Molecular Weight | 501.97 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related N Standards
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 573669-21-3)
- 4-(((7-Chloro-2-(hydroxymethyl)-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)(prop-2-ynyl)amino)-N-(pyridin-3-ylmethyl)benzamide (CAS 1258400-25-7)
- 8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-nitrophenyl)-1-oxa-4,8-diazaspiro[4.5]Decane-4-carbothioamide (CAS 338761-18-5)
- (2Z)-3-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrol-2-yl}-2-[5-(4-fluorobenzoyl)thiophen-2-yl]prop-2-enenitrile (CAS 338966-78-2)
- Ethyl 2-((7-chloro-3-(2,4-dichloro-5-isopropoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate (CAS 339099-23-9)
- 5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-N-{[(4-nitrophenyl)carbamoyl]amino}-4,5-dihydro-1,2-oxazole-3-carboxamide (CAS 338399-54-5)
- N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetamide (CAS 338409-44-2)
- 6-(2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-2-(4-chlorophenyl)pyrrolo[3,4-e][1,3]thiazine-5,7(6H,7aH)-dione (CAS 337920-05-5)
Recommended Standards
- Pitolisant impurity 24 (CAS CATO-C4X-252024)
- Dasatinib Impurity 4 (CAS 910297-53-9)
- Afatinib Impurity 11 (CAS CATO-C4X-100611)
- Benzyloxycarbonylglycyl-L-leucyl-L-phenylalanine chloromethyl ketone (CAS 41658-44-0)
- 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrimidine-2-carboxamide (CAS 1353504-93-4)
- 5-(Hydroxymethyl)-1-phenylpyrrolidine-2-thione (CAS 907563-44-4)
- Methoxychlor D14 (bis(4-methoxyphenyl D7)) (CAS 1644449-82-0)
- Methyl 1-[(N-methylglycyl)amino]cyclopentanecarboxylate trifluoroacetate (CAS 1351601-15-4)
- 2-[(2-nitro-4-sulfamoylphenyl)amino]acetic acid (CAS 848658-84-4)
- 1-(2,6-Dichlorobenzyl)-3-(2,6-dimethylmorpholine-4-carbonyl)pyridin-2(1H)-one (CAS 478048-20-3)
- 2-chloro-6-(4-chlorophenoxy)pyridine-4-carboxylic acid (CAS 42521-19-7)
- 3-cyclopropyl-2-mercaptopyrido[2,3-d]pyrimidin-4(3H)-one (CAS 688793-42-2)
- Crizotinib Impurity 48 (CAS CATO-C4X-102548)
- Semaglutide impurity 25 (CAS CATO-C4X-222625)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com