Methylprednisolone EP Impurity C CAS 61919-52-6
| CAS No. | 61919-52-6 |
| Molecular Formula | C20H26O3 |
| Molecular Weight | 314.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 314.42 g/mol gives Methylprednisolone EP Impurity C distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Methylprednisolone EP Impurity C (CAS 61919-52-6) is a certified pharmaceutical impurity reference standard with the molecular formula C20H26O3 and a molecular weight of 314.42 g/mol.
Methylprednisolone EP Impurity C (C20H26O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H26O3 |
| Molecular Weight | 314.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
Related Methylprednisolone Standards
- Methylprednisolone EP Impurity E (CAS 229019-44-7)
- Methylprednisolone EP Impurity D (CAS 1338549-02-2)
- Methylprednisolone EP Impurity G (CAS 93269-35-3)
- Methylprednisolone EP Impurity D(E-Isomer) (CAS CATO-C4X-19194)
- Methylprednisolone Impurity 79 (CAS CATO-C4X-191979)
- Methylprednisolone impurity 6 (CAS CATO-C4X-191986)
- Methylprednisolone Acetate EP Impurity I (CAS 6870-94-6)
- Methylprednisolone Impurity 57 (CAS 1048031-80-6)
Recommended Standards
- Ulipristal Impurity 30 (CAS 1383782-13-5)
- 4-Oxo Tretinoin (4-Oxo Retinoic Acid) (CAS 38030-57-8)
- Ulipristal Impurity 29 (CAS 1655514-78-5)
- Isotretinoin EP Impurity H (CAS 71748-58-8)
- Letermovir Impurity 53 (CAS CATO-C4X-291553)
- Elagolix Impurity 28 (CAS 2409132-63-2)
- Sorafenib Impurity 28 (CAS CATO-C4X-112428)
- N-(3,5-Difluorobenzyl)-1-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)methanamine hydrochloride (CAS 1856083-76-5)
- 2-Amino-3-sulfanylpropanamide hydrochloride (CAS 867-85-6)
- (1-(3,4-Difluorophenyl)ethyl)hydrazine (CAS 1016680-91-3)
- 1-Cyclohexyl-3-dodecylurea (CAS 402939-18-8)
- trans-4-(3,4-Dimethylbenzoyl)cyclohexane-1-carboxylic acid (CAS 736136-26-8)
- 5361-25-1 N-(6-Ethyl-4-methylquinazolin-2-yl)guanidine MFCD01564234 (CAS 5361-25-1)
- Des-Tyr10-Tirzepatide (CAS CATO-CPTD788680)
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