Riociguat EP Impurity A CAS 625115-52-8
| CAS No. | 625115-52-8 |
| Molecular Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Riociguat EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Riociguat EP Impurity A (CAS 625115-52-8) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17FN8O2 and a molecular weight of 408.39 g/mol.
Structurally, Riociguat EP Impurity A (C19H17FN8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 408.39 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C19H17FN8O2 |
| Molecular Weight | 408.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Riociguat Standards
- Riociguat Impurity 36 (CAS CATO-C4X-174936)
- Riociguat Impurity 41 (CAS CATO-C4X-174941)
- Riociguat EP Impurity B (CAS 3052969-92-0)
- Riociguat Impurity 18 (CAS 1361569-23-4)
- Riociguat Impurity 21 (CAS CATO-C4X-174921)
- Riociguat Impurity 11 (CAS CATO-C4X-174911)
- Riociguat Impurity 12 (CAS CATO-C4X-174912)
- Riociguat (CAS 625115-55-1)
Recommended Standards
- Vericiguat Impurity 100 (CAS 1011527-86-8)
- Tarafenacin (CAS 385367-47-5)
- Vericiguat Impurity 3 (CAS 3052969-91-9)
- 9-methyl-5-(((trifluoromethyl)sulfonyl)oxy)-2,3-dihydrobenzo[b]oxepin-8-yl pivalate (CAS 2226905-38-8)
- Ketoprofen Impurity 55 (CAS CATO-C4X-147155)
- Sugammadex Impurity Org210839-1 (CAS CATO-C4X-19064)
- Gefitinib impurity 71 (CAS CATO-C4X-111771)
- Imrecoxib Impurity 14 (CAS 959003-56-6)
- (R)-6-bromo-8-methylchroman-4-amine (CAS 1212994-77-8)
- 2-((2,3-Dihydro-1H-inden-5-yl)oxy)propanehydrazide (CAS 669745-23-7)
- 3-Cyclopropyl-5-methoxybenzoic acid (CAS 916343-79-8)
- 4-(Dimethylamino)-2-[(4-fluorophenyl)amino]pyridine-3-carbonitrile (CAS 338773-37-8)
- 4-(4-Tert-butylphenyl)-4-oxobutanoic acid (CAS 35288-08-5)
- Crustacean Cardioactive Peptide (CCAP) (CAS 309247-84-5)
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