Tadalafil impurity 10 CAS 629652-40-0
| CAS No. | 629652-40-0 |
| Molecular Formula | C22H19ClN2O5 |
| Molecular Weight | 426.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tadalafil impurity 10.
As a process- or degradation-related impurity, Tadalafil impurity 10 (CAS 629652-40-0, C22H19ClN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H19ClN2O5, Tadalafil impurity 10 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 426.85 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tadalafil impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H19ClN2O5 |
| Molecular Weight | 426.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 16 (CAS 629652-44-4)
- Tadalafil Impurity 17 (CAS 629652-42-2)
- Tadalafil Impurity 37 (CAS 171489-59-1)
- Tadalafil Impurity 67 (CAS CATO-C4X-108767)
- Tadalafil Impurity 84 (CAS CATO-C4X-108784)
- Tadalafil Impurity N23 (CAS 951661-84-0)
- Tadalafil Impurity 24 (CAS 951661-81-7)
- Tadalafil Impurity 70 (CAS CATO-C4X-108770)
Recommended Standards
- Ethyl 2-amino-4-(4-chlorophenyl)-5-cyano-6-oxo-1-((6-oxocyclohex-1-en-1-yl)amino)-1,6-dihydropyridine-3-carboxylate (CAS 341965-82-0)
- 2-Chloro-1,8-diphenoxyanthracene-9,10-dione (CAS 61601-41-0)
- Ytterbium(II) iodide (CAS 19357-86-9)
- rel-Chloropretadalafil (CAS 171596-58-0)
- Sitagliptin Impurity 122 (CAS CATO-C4X-1144122)
- Cholesterol Impurity 31 (CAS 117556-83-9)
- Doxapram Impurity 23 (CAS CATO-C4X-197323)
- 2-Fluoro-1-iodo-3-(trifluoromethyl)benzene (CAS 1416708-03-6)
- 2-(Pyridin-3-yl)tetrahydro-2H-pyran-4-amine dihydrochloride (CAS 1955520-85-0)
- 1-(3-Fluorophenyl)-2-(4-fluorophenyl)ethanone (CAS 476472-53-4)
- 4-(5-Methyl-1H-indol-3-yl)-thiazol-2-ylamine (CAS 50825-17-7)
- (5-Oxaspiro[2.4]Heptan-6-yl)methanol (CAS 2059971-81-0)
- 1-(3-Methylpiperidin-1-yl)butane-1,3-dione (CAS 92671-71-1)
- Galanin-Like Peptide (porcine) trifluoroacetate salt (CAS 245114-96-9)
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