(5E)-5-(3,4-Dichlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one CAS 6326-22-3
| CAS No. | 6326-22-3 |
| Molecular Formula | C10H5Cl2NOS2 |
| Molecular Weight | 290.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(5E)-5-(3,4-Dichlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one (CAS 6326-22-3), molecular formula C10H5Cl2NOS2 and molecular weight 290.19 g/mol, is a CATO reference standard with documented purity and traceability.
(5E)-5-(3,4-Dichlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one (C10H5Cl2NOS2) contains a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H5Cl2NOS2 |
| Molecular Weight | 290.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related E Standards
- (E)-5-(3,4-Dichlorobenzylidene)-2-mercaptothiazol-4(5H)-one (CAS 1064366-80-8)
- (5E)-5-(2,6-Dichlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one (CAS 65562-49-4)
- (5E)-5-(2,3-Dichlorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one 2729AF 90407-17-3 C10H5Cl2NOS2 (CAS 90407-17-3)
- 9-(3,4-Dichlorobenzylidene)-9H-fluorene (CAS 6967-18-6)
- N-(2,6-Dichlorobenzylidene)naphthalen-2-amine (CAS 292644-12-3)
- 5-(2,4-Dichlorobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 179808-44-7)
- N-(2,3-Dichlorobenzylidene)quinolin-6-amine (CAS 434340-87-1)
- (E)-2-(3,4-Dichlorobenzylidene)-6-hydroxybenzofuran-3(2h)-one (CAS 620545-98-4)
Recommended Standards
- 2-Chloro-N-(3-chloro-6-hydroxy-5-isopropyl-2-methylbenzyl)acetamide (CAS 26486-33-9)
- (1-Hydroxyoctane-1,1-diyl)diphosphonic acid (CAS 53019-19-5)
- 3-(4-(Bis(2-chloroethyl)amino)phenyl)propanoic acid (CAS 6746-11-8)
- tert-Butyl N-(3,4-dichlorophenyl)-N-ethylcarbamate (CAS 1881289-42-4)
- n-(Cyclohexylmethyl)-2-(4-methylcyclohexyl)ethan-1-amine (CAS 1410922-56-3)
- 2-(4-Methoxy-5-methyl-1,3-thiazol-2-yl)pyrazine (CAS 338409-47-5)
- Bis(4-((4-(dodecyloxy)benzoyl)oxy)phenyl) adipate (CAS 765954-09-4)
- Piperidine-2,3-dicarboxylic acid hydrochloride (CAS 2379651-40-6)
- 2-(3-Methyl-1-(3-methylfuran-2-yl)butylidene)hydrazinecarboxamide (CAS 17700-89-9)
- (5-Chloro-2-fluorobenzyl)hydrazine hydrochloride (CAS 1379462-59-5)
- 2-(1,1,2,3,3,3-Hexafluoropropyl)tetrahydrofuran (CAS 53005-42-8)
- N-(6-Chloro-4-(piperazin-1-yl)pyrido[3,2-d]pyrimidin-2-yl)acetamide (CAS 917758-24-8)
- 4-Benzyl-1,4,8-oxadiazecane dihydrochloride (CAS 2137936-79-7)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
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