Ciclosporin EP Impurity G CAS 63775-96-2
| CAS No. | 63775-96-2 |
| Molecular Formula | C63H113N11O12 |
| Molecular Weight | 1216.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ciclosporin EP Impurity G.
Ciclosporin EP Impurity G (CAS 63775-96-2) is a certified pharmaceutical impurity reference standard with the molecular formula C63H113N11O12 and a molecular weight of 1216.64 g/mol.
The molecular framework of Ciclosporin EP Impurity G (C63H113N11O12) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C63H113N11O12 |
| Molecular Weight | 1216.64 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Nitrogen Atoms | 11 |
Related Ciclosporin Standards
- Ciclosporin Impurity 11 (CAS CATO-C4X-199811)
- Ciclosporin Impurity 21 (CAS CATO-C4X-199821)
- Ciclosporin EP Impurity B (CAS 59865-15-5)
- Ciclosporin EP Impurity C (CAS 59865-16-6)
- Ciclosporin Impurity 12 (CAS CATO-C4X-199812)
- Ciclosporin Impurity 23 (CAS CATO-C4X-199823)
- Ciclosporin Impurity 19 (CAS CATO-C4X-199819)
- Ciclosporin Impurity 20 (CAS CATO-C4X-199820)
Recommended Standards
- Cyclosporin V (Ciclosporin EP Impurity E) (CAS 108027-46-9)
- Everolimus Impurity 23 (CAS CATO-C4X-112223)
- Cyclosporin G (CAS 74436-00-3)
- (11bS)-4-Hydroxy-9,14-dioctyl-2,6-bis(2,4,6-tricyclohexylphenyl)-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin (CAS 1803182-38-8)
- Nilotinib Impurity 25 (CAS 41574-91-8)
- Omeprazole EP Impurity H (CAS 863029-89-4)
- Anastrozole EP Impurity I (CAS 120511-91-3)
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